Rare intra-tumoral colonization of Fusobacterium nucleatum in endometrial cancer

Autor(es)

dos Reis, Mariana Bisarro ; Basso, Denise Almeida Araujo ; Bonatelli, Murilo ; Berardinelli, Gustavo Noriz ; Teixeira, Gustavo Ramos ; dos Reis, Ricardo ; Reis, Rui Manuel

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Gynecological Cancer; v. 35, n. 8, p. 5-pg., 2025-08-01.

Resumo

The presence of Fusobacterium nucleatum has been associated with gynecological disorders, namely endometriosis and pregnancy complications; however, its role in endometrial cancer remains unexplored. This study aimed to assess the presence of intra-tumoral F nucleatum in endometrial carcinoma tissues and its association with patients' clinicopathological and molecular features. A total of 260 patients were included, and a droplet digital polymerase chain reaction assay was employed to detect F nucleatum in formalin-fixed paraffin-embedded tumor tissues. F nucleatum was detected in only 3 cases (1.2%), and none exhibited high bacterial levels, even within the 79 microsatellite instability-high molecular subgroup. These findings suggest that intra-tumoral F nucleatum does not play an oncogenic role in endometrial cancer. (AU)

• Processo FAPESP: 21/13861-0 - Perfil microbioma fecal como biomarcador de detecção precoce em Câncer Colorretal em biópsia líquida
• Beneficiário: Mariana Bisarro dos Reis
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado