| Texto completo | |
| Autor(es): |
Carneiro-Ramos, Marcela Sorelli
;
Neres-Santos, Raquel Silva
;
da Silva, Jessica Veronica
;
Bedin, Beatriz Favero
;
Parletta, Aline Cristina
;
Honda, Lara Mei
;
Junho, Carolina Victoria Cruz
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Life Sciences; v. 378, p. 9-pg., 2025-10-01. |
| Resumo | |
Acute kidney injury (AKI) and chronic kidney disease (CKD) are closely linked, with AKI often accelerating CKD development through sustained inflammation, fibrosis, and tubular damage. Identifying biomarkers that track this transition is essential for early diagnosis and intervention. Recent research highlights microRNAs (miRNAs) as key regulators of AKI-to-CKD progression, with distinct expression patterns across experimental models and clinical samples. Given this context, this review consolidates recent advances in miRNA research related to the AKI-to-CKD transition. Animal studies demonstrate that miRNAs such as miR-101, miR-196a-5p, miR-874-3p, and miR-486-5p contribute to fibrosis, inflammatory signaling, and tubular cell injury-hallmarks of CKD progression. In vitro models further reveal that miRNAs drive pathological processes like epithelial-mesenchymal transition (EMT) and apoptosis, underscoring their role in kidney dysfunction at the cellular level. Clinically, miR-21 has emerged as a particularly promising biomarker, with elevated levels in urine and blood correlating with AKI severity and CKD advancement, suggesting its potential for early detection and disease monitoring. Despite growing evidence of miRNA involvement in AKI-to-CKD progression, research remains limited, particularly in translating findings into predictive diagnostic tools. Future studies should focus on validating miRNA signatures in large patient cohorts and uncovering their precise molecular mechanisms to refine therapeutic strategies. (AU) | |
| Processo FAPESP: | 23/06583-0 - Nanoespectroscopia vibracional aplicada ao estudo e caracterização de vesículas extracelulares no contexto urêmico |
| Beneficiário: | Jéssica Verônica da Silva |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 22/00153-0 - Biofotônica aplicada ao estudo de vesículas extracelulares como conectores da conversa rim-coração |
| Beneficiário: | Marcela Sorelli Carneiro Ramos |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 21/12435-8 - Impacto da lesão renal isquêmica nas alterações cardíacas observadas no quadro de Síndrome Cardiorrenal 3: contribuição das vesículas extracelulares |
| Beneficiário: | Raquel Silva Neres dos Santos |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 23/17588-2 - Efeitos da toxina urêmica p-Cresil Sulfato na viabilidade e balanço redox de células cardíacas e renais submetidas à hipóxia |
| Beneficiário: | Beatriz Favero Bedin |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |