Autor(es)

Carnio, Evelin C. ; Branco, Luiz G. S. ; Brognara, Fernanda ; Passaglia, Patricia ; Foresti, Roberta ; Motterlini, Roberto

• Tipo de documento: Artigo Científico
• Fonte: British Journal of Pharmacology; v. 182, n. 16, p. 15-pg., 2025-06-02.

Resumo

Inflammation is vital for defence against injury and infection, but excessive inflammation can lead to tissue damage and disease. The central nervous system (CNS) helps regulate immune responses through neuroendocrine pathways, such as the hypothalamic-pituitary-adrenal axis and the anti-inflammatory reflex, which limit systemic inflammation. Immune responses require significant metabolic energy and the liver adapts by increasing glucose production and mobilizing fatty acids. This immune-metabolic coordination is mediated by cytokines and metabolic regulators. This review explores how the anti-inflammatory reflex modulates the interplay between inflammation and metabolism during endotoxaemia, with a focus on the haem oxygenase 1/carbon monoxide (HO1/CO) pathway. Carbon monoxide, a byproduct of HO1 activity, acts as a key signalling molecule that reduces inflammation, supports mitochondrial function and protects tissues. Understanding this pathway provides new insights into potential therapeutic strategies for treating inflammatory and metabolic disorders by targeting neuroimmune-metabolic communication networks. (AU)

• Processo FAPESP: 14/22477-6 - ""Participação da Angiotensina-(1-7) na regulação da síntese e liberação de vasopressina durante a endotoxemia
• Beneficiário: Patrícia Passaglia
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 15/09857-7 - Ação central de angiotensina (1-7) sobre a liberação de vasopressina durante o choque endotoxêmico.
• Beneficiário: Evelin Capellari Cárnio
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 21/05554-0 - Identificação de mediadores da resposta inflamatória nas aferências barorreceptoras de ratos submetidos à inflamação sistêmica
• Beneficiário: Evelin Capellari Cárnio
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 21/03764-8 - Identificação de receptores de citocinas e do receptor Toll-like 4 nas aferências barorreceptoras de ratos submetidos à inflamação sistêmica
• Beneficiário: Fernanda Brognara Penteado Dias
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado