| Texto completo | |
| Autor(es): |
Fajardo, Thamirys Cosmo Grillo
;
de Quadros Junior, Antonio Carlos
;
Pinto, Clovis Antonio Lopes
;
Dos Santos, Geovane Ribeiro
;
da Silva, Andrea Cristina Botelho
;
Catalan, Daniel Thome
;
Bertozzi, Ana Paula Antunes Pascalicchio
;
Gazeta, Rosa Estela
;
Moron, Antonio Fernandes
;
Passos, Saulo Duarte
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Revista do Instituto de Medicina Tropical de São Paulo; v. 67, p. 7-pg., 2025-01-01. |
| Resumo | |
Evidence suggests arisk of maternal transmission of chikungunya virus (CHIKV) during the first and third trimesters, potentially leading to miscarriage or neurological consequences for the fetus. This study aimed to conduct a serological survey for CHIKV among women with high-risk pregnancies and analyze neonatal variables and placental tissue alterations. From March 2016 to April 2021, serological, histological, and molecular tests for CHIKV were performed. Blood samples were analyzed for anti-CHIKV IgG and IgM antibodies, and placental tissue was examined for CHIKV RNA and histological changes. Among pregnant patients, 1.33% (7/526) had reactive IgG, and 0.38% (2/526) had IgM/IgG-type antibodies during delivery. Although placental histology of CHIKV disease showed alterations, no viral genetic material was identified in the analyzed tissues. Therefore, further research is needed, including the use of complementary diagnostic techniques, to better understand the impact of this relatively new disease among high-risk pregnant women and newborns. (AU) | |
| Processo FAPESP: | 16/08578-0 - Infecção vertical pelo vírus Zika e suas repercussões na área materno-infantil |
| Beneficiário: | Saulo Duarte Passos |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 17/22007-8 - Infecção vertical pelo vírus Zika e suas repercussões na área materno-infantil |
| Beneficiário: | Danila Vedovello de Jesus |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |