The Effects of Transcranial Direct Current Stimulation During Extended Reality Exercises for Cortical, Neuromuscular, and Clinical Recovery of Stroke Survivors

Autor(es)

Ruas, Cassio V. ; Carlos, Bruna M. ; Feitosa, Saulo ; Silva, Marcio Vinicius ; Vazquez, Pedro ; Pontes, Larissa L. ; Silvestre, Jayne ; Almeida, Sara R. M. ; Brandao, Alexandre F. ; Castellano, Gabriela

• Tipo de documento: Artigo Científico
• Fonte: NEURAL PLASTICITY; v. 2025, n. 1, p. 16-pg., 2025-01-01.

Resumo

Background: Rehabilitation methods that include anodal transcranial direct current stimulation (atDCS) and extended reality (XR) exercises have been used to enhance neural networks and improve functional performance in stroke patients, but the neuromuscular and neurophysiological mechanisms underlying these improvements are not fully understood. The purpose of this study was to examine the effects of atDCS during XR rehabilitation exercises on cortical, neuromuscular, and clinical outcomes of stroke survivors. Methods: Nineteen chronic stroke survivors were placed into either a transcranial direct current stimulation (tDCS) or a Sham group, without significant (p > 0.73) differences in the baseline levels of disability between groups. The tDCS group received active atDCS and the Sham group received sham atDCS applied on the ipsilesional primary motor cortex (M1) while performing a 10-session XR rehabilitation program. Surface electromyography (EMG) activity was recorded from deltoid and rectus femoris of the paretic limb without and with the application of active/sham atDCS on the M1. Shoulder abduction and hip flexion active maximum joint range of motion (ROMmax), electroencephalography (EEG)-derived brain symmetry index (BSI) and functional/clinical tests were assessed before and after the rehabilitation program. Results: EMG activity was similar to 31% greater during hip flexion of the paretic limb with the application of active atDCS than without atDCS (p = 0.04). Paretic hip flexion ROMmax increased by similar to 26%, BSI decreased by similar to 72% (indicating greater brain symmetry) and timed up and go (TUG) functional test improved by similar to 11% from before to after the rehabilitation program for the tDCS group only (p < 0.05). No other significant differences (p > 0.05) were observed. Conclusion: It seems that the application of active atDCS targeted the ipsilesional M1 representation of the quadriceps, which potentiated muscle activation in the paretic rectus femoris during XR exercises and resulted in greater motor recovery in hip flexion movements. The EEG-derived BSI results also indicate that atDCS was effective in reorganizing the ipsilesional hemisphere brain activity after stroke. (AU)

• Processo FAPESP: 23/11024-0 - Alterações de conectividade funcional em pacientes neurológicos
• Beneficiário: Bruna Mezzari Carlos
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 22/08057-0 - Neuromodulação combinada a outras neurotecnologias para aplicação na reabilitação motora de pacientes de AVC
• Beneficiário: Cássio Víctora Ruas
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN
• Beneficiário: Fernando Cendes
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs