Creatine monohydrate supplementation for older adults and clinical populations

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Candow, Darren G. ; Ostojic, Sergej M. ; Chilibeck, Philip D. ; Longobardi, Igor ; Gualano, Bruno ; Tarnopolsky, Mark A. ; Wallimann, Theo ; Moriarty, Terence ; Kreider, Richard B. ; Forbes, Scott C. ; Schlattner, Uwe ; Antonio, Jose

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION; v. 22, p. 32-pg., 2025-09-30.

Resumo

BackgroundThe biological process of aging is typically associated with a decrease in muscle quantity, muscle performance (primarily strength), bone mass and architecture, functionality and neurological/cognitive function. From a healthy aging perspective, interventions that have the potential to overcome or attenuate these decrements are clinically relevant.MethodsWe conducted a narrative review on the efficacy of creatine monohydrate supplementation (CrM) in older adults.ResultsAccumulating research shows that CrM, primarily when combined with exercise training, is safe and has beneficial effects on measures of whole-body lean body mass, regional muscle size, muscle strength, bone area and thickness, functional ability, glucose kinetics, cognition and memory.ConclusionCrM has multiple benefits in older adults and may have application for treating age-related sarcopenia, osteoporosis, frailty, and those with metabolic and neuromuscular disorders. (AU)

• Processo FAPESP: 21/13580-1 - Efeitos de um programa de treinamento físico domiciliar sobre a qualidade de vida e parâmetros de saúde de pacientes sobreviventes à COVID-19 grave
• Beneficiário: Igor Longobardi Amin
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto