| Texto completo | |
| Autor(es): |
Paulino, Julia Mirian
;
Goncalves, Natalia dos Santos
;
Andrada, Heber Eduardo
;
Ribeiro, Arthur Barcelos
;
Ramos, Carlos Henrique Inacio
;
Mizuno, Cassia Suemi
;
dos Santos, Raquel Alves
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NATURAL PRODUCT RESEARCH; v. N/A, p. 8-pg., 2025-09-27. |
| Resumo | |
The present study investigated the cellular inhibitory effects of cis-trimethoxystilbene (cis-TMS) on the chemoresistant MDA-MB-231 breast cancer cell line and the role of p53 in mediating the cellular responses to this compound. Treatment with cis-TMS significantly inhibited the growth of MDA-MB-231 cells, reducing the cell viability by approximately 75% at 2.5 mu M and increasing apoptosis rates to nearly 20%. Silencing p53 in MCF-10A and MCF-7 cell lines revealed that cis-TMS-induced apoptosis and cell cycle arrest were p53-dependent. The interaction studies suggest that cis-TMS does not alter the conformation of p53 at low concentrations but may influence its activity at higher doses. The results suggest that cis-TMS selectively targets cancer cells with functional p53, offering a potential targeted therapy approach. However, the reliance on p53 and the risk of genomic instability pose limitations, requiring further research to optimise the therapeutic strategies involving cis-TMS. (AU) | |
| Processo FAPESP: | 18/16461-0 - Efeito do tratamento com cis-trimetoxiestilbeno após o silenciamento de TP53 por siRNA nas linhagens tumorais MCF-7 e MDA-MB-231: uma abordagem celular e molecular |
| Beneficiário: | Raquel Alves dos Santos |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |