| Texto completo | |
| Autor(es): |
Galetti, Renata
;
Casarin Penha Filho, Rafael Antonio
;
Ferreira, Joseane Cristina
;
Varani, Alessandro M.
;
Sazinas, Pavelas
;
Jelsbak, Lars
;
Costa Darini, Ana Lucia
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | INFECTION GENETICS AND EVOLUTION; v. 89, p. 4-pg., 2021-01-22. |
| Resumo | |
The rapid emergence of resistant bacteria is occurring worldwide. The understanding of the dissemination of antimicrobial resistance using high-throughput sequencing and bioinformatics approaches is providing valuable insights into the genetic basis of the horizontal gene transfer and the emergence of the antibiotic resistance threat. This ultimately can offer vital clues to the development of coordinated efforts to implement new policies to continue fighting against bacterial infections. The poultry microbiota is characterized as a potential reservoir of resistance genes, mostly derived from the Enterobacteriaceae which have become increasingly important in human and animal infections. In this work, complete genome sequences were achieved for four multidrugresistant Salmonella spp. isolated from poultry from different farms in Brazil. We identified highly similar IncHI2-ST2 megaplasmids (larger than 275.000 bp) in all Salmonella isolates studied. These megaplasmids carry a resistome comprised of eleven different resistance genes (aac(6?)-Iaa, aadA1b, aph(4)-Ia, aph(6)-Id, aph(3?)-Ib, aph(3?)-Ia, aac(3)-Iva, sul1, tetA, tetB and dfrA1b) and four heavy metal tolerance operons (telluride, mercury, silver and copper). In conclusion, the multidrug-resistant plasmids identified in S. enterica serovar Schwarzengrund and Newport isolated from poultry show a variety of antibiotic resistance and heavy metal tolerance genes, providing advantages for the bacteria to survive under extremely unfavorable conditions. (AU) | |
| Processo FAPESP: | 15/11728-0 - Sequenciamento completo de plasmídeos carreando genes de resistência a antibióticos em bactérias de interesse e análise do genoma de linhagens de Pseudomonas aeruginosa produtoras de SPM-1 e de KPC-2 por sequenciamento em larga escala |
| Beneficiário: | Renata Galetti |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 14/14494-8 - Epidemiologia molecular de bactérias gram-negativas e genética da resistência a antibióticos |
| Beneficiário: | Ana Lúcia da Costa Darini |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 17/26311-3 - Sequenciamento em larga escala de plasmídeos carreando genes de resistência a antibióticos isolados de Enterobacteriaceae isoladas de frangos |
| Beneficiário: | Renata Galetti |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado |