| Texto completo | |
| Autor(es): |
Ribeiro, Arthur Barcelos
;
Junqueira, Marcela de Melo
;
Furtado, Ricardo Andrade
;
Bastos, Jairo Kenupp
;
Crispim Tavares, Denise
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES; v. N/A, p. 13-pg., 2025-09-13. |
| Resumo | |
Pediatric high-grade gliomas remain a significant therapeutic challenge due to their resistance to conventional treatments. The aim of this study was to investigate the cytotoxic potential of solamargine (SM), a natural glycoalkaloid, alone and in combination with the chemotherapeutic agent temozolomide (TMZ) against the human KNS-42 glioma cell line. Solamargine significantly reduced cell viability and proliferation in a concentration-, time-, and hypoxia-dependent manner, while selectively sparing non-tumor human astrocytes (NHA). Morphological changes indicative of cell stress and death were observed, although SM did not markedly impair the migratory capacity of KNS-42 cells. In contrast, TMZ exhibited limited cytotoxicity against KNS-42 cells but demonstrated off-target effects on NHA cells. Combination therapy resulted in significant antagonism, with TMZ diminishing the cytotoxic effects of SM. These findings indicate the potential of SM to serve as a selective therapeutic agent for gliomas. Data obtained emphasize (1) the need for further research to optimize combination strategies and (2) to elucidate the underlying mechanisms of drug interactions. (AU) | |
| Processo FAPESP: | 22/00806-4 - Caracterização do potencial antitumoral da solamargina frente ao Glioblastoma humano |
| Beneficiário: | Denise Crispim Tavares |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |