| Texto completo | |
| Autor(es): |
Costa, Ericka Francislaine Dias
;
Ferreira, Ana Maria Castro
;
Mazzali, Marilda
;
Lourenco, Gustavo Jacob
;
Lima, Carmen Silvia Passos
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. 47, n. 10, p. 10-pg., 2025-05-08. |
| Resumo | |
Background: This study investigated the roles of single nucleotide variants (SNVs) in genes of CDDP metabolism and their association with kidney dysfunction in patients with head and neck squamous cell carcinoma (HNSCC). Methods: A total of 109 patients with locally advanced HNSCC, treated with CDDP, had renal function evaluated by serum creatinine level and CKD-EPI formula, and underwent genotyping by polymerase chain reaction. Results: Patients with GSTT1 present and ERCC1 c.354CT or TT genotypes showed 4.94% and 8.94% renal function reduction, respectively. GSTT1 present with TP53 c.215G>C (17.67%), GSTP1 c.313A>G with ERCC1 c.354C>T (17.57%), GSTP1 c.313A>G with MLH1 c.93G>A (12.49%), GSTP1 c.313A>G with MSH3 c.3133A>G (12.19%), ERCC1 c.354C>T with MLH1 c.93G>A (18.85%) and ERCC1 c.354C>T with MSH3 c.3133A>G (13.38%) combined genotypes were also associated with substantial declines in renal function. Conclusions: Our data suggest that isolated and combined SNVs in genes enrolled in CDDP metabolism can be used to select patients for treatments that spare the kidneys from adverse effects. (AU) | |
| Processo FAPESP: | 12/01807-2 - Farmacogenética da cisplatina em portadores de carcinoma de células escamosas de cabeça e pescoço |
| Beneficiário: | Carmen Silvia Passos Lima |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 21/10265-8 - Centro de Inovação Teranóstica em Câncer (CancerThera) |
| Beneficiário: | Carmino Antonio de Souza |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |