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| Autor(es): Mostrar menos - |
Nardy, Ariane
;
Monteiro, Fernanda Rodrigues
;
Silva, Brenda Rodrigues
;
do Amaral, Jonatas Bussador
;
Leal Oliveira, Danielle Bruna
;
Candido, Erika Donizetti de Oliveira
;
Luiz Durigon, Edison
;
Aguiar, Andressa Simoes
;
Scagion, Guilherme Pereira
;
Chalup, Vanessa Nascimento
;
Furtado, Guilherme Eustaquio
;
Shio, Marina Tiemi
;
Franca, Carolina Nunes
;
Nali, Luiz Henrique da Silva
;
Bachi, Andre Luis Lacerda
Número total de Autores: 15
|
| Tipo de documento: | Artigo Científico |
| Fonte: | VACCINES; v. 13, n. 8, p. 21-pg., 2025-07-24. |
| Resumo | |
Background: Chronic cytomegalovirus (CMV) infection may favor the development of immunosenescence and inflammation that impair vaccine responses, including COVID-19. In addition, the polymorphism of the interferon-lambda gene (IFN lambda) affects COVID-19 immune responses in older adults. Objective: We aimed to investigate the impact of IFN lambda polymorphism (IL28B gene-rs12979860) on the immune/inflammatory response to vaccination with CoronaVac for COVID-19 in older adults who were CMV-seropositive. Methods: Blood samples from 42 CMV-seropositive older adults (73.7 +/- 4.5 years) were collected before and 30 days after immunization with a second dose of the CoronaVac vaccine to evaluate the immune/inflammatory response. Results: At genotyping, 20 subjects were homozygous for the C/C alleles (Allele-1 group), 5 were homozygous for the T/T Alleles (Allele-2 group), and 17 were heterozygous (C/T, Alleles-1/2 group). The Allele-1 group showed higher IgG levels for COVID-19 (p = 0.0269) and intermediate monocyte percentage (p = 0.017), in contrast to a lower non-classical monocyte percentage (p = 0.0141) post-vaccination than pre-vaccination. Also, this group showed that IgG levels for CMV were positively associated with a systemic pro-inflammatory state and senescent T cells (CD4+ and CD8+). The Allele-2 group presented higher IFN-beta levels at pre- (p = 0.0248) and post-vaccination (p = 0.0206) than the values in the Allele-1 and Alleles-1/2 groups, respectively. In addition, the Allele-2 and Alleles-1/2 groups showed that IgG levels for COVID-19 were positively associated with a balanced systemic inflammatory state. Conclusion: CMV-seropositivity in older adults who had Allele-1 could lead to an unbalanced systemic inflammatory state, which may impair their antibody response to COVID-19 vaccination compared to other volunteer groups. (AU) | |
| Processo FAPESP: | 22/02030-3 - Impacto da soropositividade para Citomegalovírus (CMV) e do perfil da microbiota na resposta imune/inflamatória sistêmica e nas vias aéreas superiores de idosos vacinados para doenças respiratórias |
| Beneficiário: | André Luis Lacerda Bachi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 19/14115-0 - Influência da suplementação de L-glutamina na sarcopenia e resposta imune/inflamatória sistêmica e das vias aéreas de idosos praticantes ou não de um programa regular de exercícios físicos combinados submetidas à vacinação contra o vírus Influenza |
| Beneficiário: | André Luis Lacerda Bachi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 20/11561-7 - Avaliação dos interferons do polimorfismo para interferon-lambda e de anticorpos específicos para sars-cov-2 e citomegalovírus em idosos |
| Beneficiário: | Ariane Nardy |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |