Parvovirus among Patients with Cytopenia of Unknown Origin in Brazil: a Case-Control Study

Autor(es)

Garcia, Sheila de Oliveira ^[1] ; Kleine Neto, Walter ^{[2, 3]} ; da Costa, Antonio Charlys ^[2] ; Sanabani, Sabri Saeed ^[2] ; Mendrone, Jr., Alfredo ^[3] ; Pereira, Juliana ^[1] ; Sabino, Ester Cerdeira ^{[4, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Dept Hematol, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Translat Med, Sao Paulo - Brazil

^[3] Hemoctr Sao Paulo, Fundacoes Prosangue, BR-05403000 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Infect Dis, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Clinical Microbiology; v. 49, n. 4, p. 1578-1580, APR 2011.
• Citações Web of Science: 3

Resumo

The molecular prevalence of human parvovirus B19V (B19V) in bone marrow (BM) samples from 120 cases with cytopenias of unknown etiology was compared with that in samples from 45 BM donors (control group 1) and 120 oncohematological patients (control group 2) to determine the role that B19V genotypes may play in unexplained cytopenias. Of the 285 participants, the BM samples of 39 (13.7%) contained B19V DNA (21 with genotype 1, 5 with genotype 2, and 13 with genotype 3). The prevalences of B19V were similar between case and control subjects (15.0% versus 12.7%, respectively). Genotypes 2 and 3 were associated with older age and were detected in similar proportions between case and control group 2 subjects. The results of this study do not support a role for B19V genotype variants in the etiology of unexplained cytopenias. (AU)

• Processo FAPESP: 06/55708-4 - O significado das variantes dos eritrovirus em pacientes com citopenias: um estudo de caso-controle.
• Beneficiário: Ester Cerdeira Sabino
• Modalidade de apoio: Auxílio à Pesquisa - Regular