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Peptides from frog skin for wound repair: a systematic review

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Assis, Livia ; Souza, Amanda ; Avanzi, Ingrid Regina ; Sousa, Karolyne S. Jorge ; Santo, Giovanna E. ; Do Amaral, Gustavo O. ; De Souza, Joao Pedro Mathias ; Parisi, Julia ; Martignago, Cintia Cristina S. ; Ribeiro, Daniel Arai ; Renno, Ana Claudia
Número total de Autores: 11
Tipo de documento: Artigo Científico
Fonte: Anais da Academia Brasileira de Ciências; v. 97, n. 3, p. 16-pg., 2025-01-01.
Resumo

Skin wounds are common injuries, and many treatments have been proposed, especially membranes. Some studies have been exploring the potential of the skin of Amphibians as a source of peptides for wound treatment, which has been an extremely promising source of bioactives to be used, although there is a lack of effects on preclinical animal models, which makes it difficult to understand the results and the choice of the best protocol to use. In this context, the purpose of this study was to perform a systematic review of the literature to examine the effects of membranes manufactured with peptides from frogs on the process of healing skin wounds using in vivo experimental models. This systematic review was carried out based in the orientations of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) utilizing PubMed, Scopus and Web of Science databases. This review confirms the significant benefits of using these peptides for injury repair and regeneration. Moreover, a faster healing and a full wound closure, with well-organized dermal and epidermal layers were found in the wounds treated peptides from frog skin. (AU)

Processo FAPESP: 21/02974-9 - Rede interdisciplinar para o desenvolvimento biotecnológico de biomateriais de origem marinha para uso na saúde humana: acometimentos patológicos do sistema osteoarticular
Beneficiário:Cintia Cristina Santi Martignago
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 21/13056-0 - Impressão 3D de curativos cutâneos de colágeno de esponjas marinhas e pele de peixe: estudo comparativo para aplicação no tratamento de feridas cutâneas
Beneficiário:Amanda de Souza
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 23/10998-0 - Efeito da pele de rã associada ou não a fotobiomodulação no reparo da pele: um estudo "in vitro" e "in vivo"
Beneficiário:Lívia Assis Garcia
Modalidade de apoio: Auxílio à Pesquisa - Regular