| Texto completo | |
| Autor(es): Mostrar menos - |
Andrioli, Willian J.
;
Conti, Raphael
;
Araujo, Magali J.
;
Zanasi, Riccardo
;
Cavalcanti, Bruno C.
;
Manfrim, Viviane
;
Toledo, Juliano S.
;
Tedesco, Daniele
;
de Moraes, Manoel O.
;
Pessoa, Claudia
;
Cruz, Angela K.
;
Bertucci, Carlo
;
Sabino, Jose
;
Nanayakkara, Dhammika N. P.
;
Pupo, Monica T.
;
Bastos, Jairo K.
Número total de Autores: 16
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Natural Products; v. 77, n. 1, p. 9-pg., 2014-01-01. |
| Resumo | |
Three new azaphilones with an unusual methylene bridge, named mycoleptones A, B, and C (2, 4, and 5), were isolated from cultures of Mycoleptodiscus indicus, a fungus associated with the South American medicinal plant Borreria verticillata. Additionally, four known polyketides, austdiol (1), eugenitin (3), 6-methoxyeugenin (6), and 9-hydroxyeugenin (7), were also isolated. The structural characterization of compounds was carried out by nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, electronic circular dichroism spectroscopy, time-dependent density functional theory calculations, and X-ray crystallography. Compounds 1-9 were weakly active when tested in antileishmanial and cytotoxicity assays. (AU) | |
| Processo FAPESP: | 04/07935-6 - Bioprospecção de fungos: a busca de compostos importantes para o projeto de remédios e enzimas para aplicações farmacêuticas e industriais |
| Beneficiário: | Jairo Kenupp Bastos |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Temático |
| Processo FAPESP: | 07/58650-0 - Otimizacao das condicoes de cultivo de beauveria bassiana e fungo endofitico fb59 visando a producao de metabolitos com atividades antimicrobiana, antiparasitaria e antiumoral |
| Beneficiário: | Willian Jonis Andrioli |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |