Autor(es)

Araque Gelves, Dayanna Isabel ; Andreoli de Souza, Giulia Cristina ; Salvador, Marcos Jose ; Diaz-Rodriguez, Alondra Maria ; Campos-Avelar, Ixchel ; de los Santos-villalobo, Sergio

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF PLANT GROWTH REGULATION; v. N/A, p. 28-pg., 2025-10-28.

Resumo

Bioactive compounds are molecules synthesized by living organisms that have beneficial effects on human health. Among them, secondary metabolites (SMs) are produced by plants in response to environmental interactions, acting as a defense against abiotic or biotic stress. Their synthesis is influenced by factors such as temperature, light, nutrient availability, and CO2, as well as by interactions with endophytic, mycorrhizal, and rhizospheric microorganisms. These plant-microorganism interactions can induce or enhance the production of SMs, including phenols, alkaloids, terpenoids, and phytohormones. Microorganisms not only activate specific metabolic pathways but can also share biosynthetic pathways or act as elicitors. Plants modulate their microbiome through environmental conditions and molecular signals, shaping microbial communities with key roles in growth, stress tolerance, and production of bioactive compounds. These associations represent a promising biotechnological strategy for sustainable pharmaceutical, agricultural, and environmental applications. This review further explores innovative biotechnological strategies such as co-cultivation systems, synthetic microbial communities (SynComs), omics-based approaches, and genetic engineering to optimize metabolite yield and functionality. Overall, it highlights the potential of harnessing plant-microbe interactions as a sustainable and scalable source of bioactive compounds, contributing to ecosystem resilience and biotechnological innovation. (AU)

• Processo FAPESP: 06/06079-4 - Busca de antioxidantes e antimicrobianos em espécies da tribo Gomphreneae
• Beneficiário: Marcos José Salvador
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/03726-8 - Estudo químico e biológico integrado para a busca de substâncias bioativas em espécies vegetais* e desenvolvimento de procedimentos analíticos. *(Amaranthaceae, Gesneriaceae, Myrtaceae e Annonaceae)
• Beneficiário: Marcos José Salvador
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 21/09693-5 - Emprego de tecnologias de microbioma e bioensaios para a busca de novas substâncias bioativas em plantas e simbiontes: implicações nas respostas metabólicas, na diversidade molecular e na bioatividade
• Beneficiário: Marcos José Salvador
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Regular
• Processo FAPESP: 17/03598-5 - Efeito preventivo de preparações com Ilex paraguariensis (chimarrão, terere e chá mate) contra os danos causados pelo consumo crônico de etanol: análise comparativa da tecnologia de preparo, perfil químico e avaliação do efeito e segurança terapeutica
• Beneficiário: Mariana Mesquita Fonseca
• Modalidade de apoio: Bolsas no Brasil - Doutorado