Autor(es)

Ferreira, Leticia do Nascimento Maximiano ; Norde, Marina Maintinguer ; Aguirre, Raquel Arriola ; Neto, Joao Valentini ; Fisberg, Regina Mara ; Sarti, Flavia Mori ; Giovannucci, Edward ; Rogero, Marcelo Macedo

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION; v. 142, p. 13-pg., 2025-11-19.

Resumo

Introduction: Inflammatory dietary indices and dietary quality indices are frequently applied to investigate the inflammatory potential of diets. However, their relative ability to explain plasma inflammatory biomarker concentrations remains unclear. Objective: To compare the effectiveness of the Dietary Inflammatory Index (DII), the Empirical Dietary Inflammatory Pattern adapted to the Sao Paulo population (EDIP-SP), and the Global Diet Quality Score (GDQS) in explaining plasma inflammatory biomarker concentrations. Methods: A cross-sectional population-based study was conducted with 501 participants from the 2015 Health Survey of Sao Paulo. Dietary data were assessed through two nonconsecutive 24-h dietary recalls, and the DII, EDIP-SP, and GDQS were scored. Plasma concentrations of high-sensitive C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-a), and adiponectin were determined. Multivariable-adjusted linear regression models were used to investigate the associations between dietary indices and inflammatory biomarkers. Model fit was compared using the coefficient of determination and the Akaike Information Criterion. Results: The EDIP-SP was positively associated with plasma CRP concentrations in the multivariable analysis adjusted for body mass index. The DII showed an effect modification by sex in association with plasma CRP concentrations. The GDQS submetric composed of healthy food groups was inversely associated with CRP and positively associated with adiponectin concentrations. No significant associations were observed between dietary index scores and plasma TNF-a. No substantial differences in model fit were observed among the dietary indices for explaining plasma inflammatory biomarker concentrations, except for CRP, which presented a higher percentage of variance explained by EDIP-SP. Conclusion: The EDIP-SP and DII explained plasma inflammatory biomarker concentrations more consistently than the GDQS, indicating that dietary inflammatory indices were more effective for capturing systemic lowgrade inflammation. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. (AU)

• Processo FAPESP: 17/05125-7 - Estilo de vida, marcadores bioquímicos e genéticos como fatores de risco cardiometabólico: inquérito de saúde na cidade de São Paulo
• Beneficiário: Regina Mara Fisberg
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 24/10729-2 - Desempenho do Índice Inflamatório da Dieta ajustado pela energia, do Índice Empírico de Inflamação da Dieta adaptado à população de São Paulo e do Escore Global de Qualidade da Dieta para prever as concentrações plasmáticas de biomarcadores inflamatórios
• Beneficiário: Letícia do Nascimento Maximiano Ferreira
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado