| Texto completo | |
| Autor(es): Mostrar menos - |
Touitou, Meir
;
Manetti, Fabrizio
;
Ribeiro, Camila Maringolo
;
Pavan, Fernando Rogerio
;
Scalacci, Nicolo
;
Zrebna, Katarina
;
Begum, Neelu
;
Semenya, Dorothy
;
Gupta, Antima
;
Bhakta, Sanjib
;
McHugh, Timothy D.
;
Senderowitz, Hanoch
;
Kyriazi, Melina
;
Castagnolo, Daniele
Número total de Autores: 14
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ACS Medicinal Chemistry Letters; v. 11, n. 5, p. 7-pg., 2020-05-14. |
| Resumo | |
A series of N-phenyl-2,5-dimethylpyrrole derivatives, designed as hybrids of the antitubercular agents BM212 and SQ109, have been synthesized and evaluated against susceptible and drug-resistant mycobacteria strains. Compound 5d, bearing a cyclohexylmethylene side chain, showed high potency against M. tuberculosis including MDR-TB strains at submicromolar concentrations. The new compound shows bacteriostatic activity and low toxicity and proved to be effective against intracellular mycobacteria too, showing an activity profile similar to isoniazid. (AU) | |
| Processo FAPESP: | 18/00163-0 - Desenvolvimento e busca de novos antimicrobianos contra Tuberculose: da triagem a estudos pré-clínicos in vivo |
| Beneficiário: | Fernando Rogério Pavan |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |