| Texto completo | |
| Autor(es): |
dos Santos, Thiago
;
Grundke, Caroline
;
Lucas, Tobias
;
Grossmann, Luca
;
Clososki, Giuliano Cesar
;
Opatz, Till
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY; v. 2020, n. 41, p. 4-pg., 2020-08-30. |
| Resumo | |
Carbohydrates such as glucose are an abundant renewable resource that can be employed in synthetic processes as a source of carbon and/or hydrogen to yield products of high economical and biological impact. Herein, we report a versatile and environmentally friendly protocol for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones, a privileged scaffold in medicinal chemistry, based on the use of glucose as an eco-friendly reductant in alkaline aqueous medium. This method can be viewed as a blueprint for the development of further one-pot sequences involving glucose as a reductant. (AU) | |
| Processo FAPESP: | 18/14150-8 - Funcionalização seletiva de aromáticos: estudos metodológicos e novas aplicações na síntese de substâncias bioativas |
| Beneficiário: | Giuliano Cesar Clososki |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |