| Texto completo | |
| Autor(es): |
Campos, Debora L.
;
Machado, Ignacio
;
Ribeiro, Camila M.
;
Gambino, Dinorah
;
Pavan, Fernando R.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF ANTIBIOTICS; v. 73, n. 2, p. 5-pg., 2020-02-01. |
| Resumo | |
The objective of this study was to determine the activity of pyridine-2-thiol 1-oxide sodium salt (Na mpo) and its complex with iron [Fe(mpo)(3)] against Mycobacterium tuberculosis. The compounds were tested against a standard strain of M. tuberculosis H(37)Rv (ATCC 27294), with minimal inhibitory concentrations (MIC90) of 7.20 and 1.07 mu M to Na mpo and [Fe(mpo)(3)], respectively, and against three clinical isolates with different genotypic profiles, with MIC values ranging from 0.74 to 6.52 and 0.30 to 2.25 mu M to Na mpo and [Fe(mpo)(3)], respectively. [Fe(mpo)(3)] was more effective against susceptible strains but both compounds were effective in inhibiting MDR and XDR-TB clinical strains. The profile activity was determined through the methodology of a time-kill curve against standard and clinical strains of M. tuberculosis. Time-kill studies indicated that Na mpo had an early bactericidal activity against H(37)Rv and clinical isolates, with sterilizing effects observed in 5 and 7 days, respectively, at its MIC90. The anti MDR and XDR-M. tuberculosis activity and bactericidal effect of Na mpo and [Fe(mpo)(3)] demonstrate their potential as new compounds for the treatment of tuberculosis. (AU) | |
| Processo FAPESP: | 13/14957-5 - Investigação do potencial contra tuberculose de uma nova classe de compostos furoxânicos e compostos nanoestruturados de rutênio(II) e cobre(II) |
| Beneficiário: | Fernando Rogério Pavan |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 18/00163-0 - Desenvolvimento e busca de novos antimicrobianos contra Tuberculose: da triagem a estudos pré-clínicos in vivo |
| Beneficiário: | Fernando Rogério Pavan |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |