| Texto completo | |
| Autor(es): |
Goncalves, Carlos Eduardo da Silva
;
Santos, Andressa Antunes
;
Sartori, Talita
;
da Silva, Renaira Oliveira
;
Vivian, Gabriela Kodja
;
de Matos, Luciene Assaf
;
Neves, Bruna Roberta Oliveira
;
Casagrande, Juliana Gimenez
;
Fock, Ricardo Ambrosio
;
Hastreiter, Araceli Aparecida
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | STEM CELLS AND DEVELOPMENT; v. 34, n. 23, p. 9-pg., 2025-12-01. |
| Resumo | |
Vitamins are well known for their essential role in maintaining organismal homeostasis by directly influencing the function of a variety of cells. Among the tissues crucial for sustaining life is the bone marrow, where the highly organized and demanding daily production of billions of new blood cells occurs through a process known as hematopoiesis. At the apex of the hematopoietic hierarchy lie hematopoietic stem cells (HSCs), undifferentiated cells with multilineage potential that maintain themselves through extensive networks of cell-intrinsic and cell-extrinsic interactions. Despite considerable efforts to unravel these regulatory networks, the ways in which most vitamins influence the delicate balance of blood homeostasis remain largely unexplored. In this review, we summarize the current body of evidence linking vitamins to HSC metabolism and progeny, with a particular focus on preclinical findings that highlight the role of vitamins in maintaining hematopoietic tissue function. A deeper understanding of the contributions of vitamins to blood cell production could pave the way for innovative therapeutic approaches against hematological diseases. (AU) | |
| Processo FAPESP: | 24/09422-0 - Efeitos bystander induzidos por células-tronco mesenquimais irradiadas e a influência sobre os controles da hematopoese: proliferação, diferenciação, maturação e migração |
| Beneficiário: | Ricardo Ambrósio Fock |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 23/03938-1 - Avaliação dos efeitos da desnutrição proteica e da renutrição sob aspectos de controle da hematopoese: participação das semaforinas classe 3 e 4 |
| Beneficiário: | Carlos Eduardo da Silva Gonçalves |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |