Autor(es)

Isikawa, Mileni M. ; Muradova, Zeinaf ; dos Santos, Ettore A. ; Piva, Henrique L. ; Morris, Toby ; Tedesco, Claudio A. ; Berbeco, Ross I. ; Guidelli, Eder J.

• Tipo de documento: Artigo Científico
• Fonte: MATERIALS TODAY CHEMISTRY; v. 51, p. 14-pg., 2026-01-01.

Resumo

Delivering oxygen to tumors remains a significant challenge in enhancing radiotherapy efficacy. Here, we synthesized ultrasmall gold (Au) coated with an anthracene shell for singlet oxygen delivery (1O2). We assessed 1O2 trapping via fluorescence spectroscopy, while its release was investigated using both electron spin resonance (ESR) and fluorescence spectroscopy. ESR and DPBF results indicated the possibility of activating cycloreversion and releasing 1O2 using X-rays instead of heat or UV light. This is a tremendous advantage because X-rays are highly penetrating and commonly employed for cancer treatments. The 1O2 release upon X-ray irradiation was only observed for the hybrid core-shell nanoparticles and not for pure anthracene nanoparticles, suggesting that the electron shower emitted from the Au cores during the X-ray irradiation can break the 1O2 bond to the aromatic ring at the anthracene shell. Therefore, the hybrid core-shell structure is essential to enable the X-ray-triggered 1O2 release. Clonogenic experiments evidenced a statistically significant smaller survival fraction of A549 cancer cells only when treated with the core-shell nanoparticles loaded with 1O2 and irradiated with Xrays. Therefore, the hybrid nanoparticles produced here hold promise in cancer treatments for triggering the release of oxygen with X-rays, enhancing radiotherapy efficacy. (AU)

• Processo FAPESP: 24/21657-2 - Do Oxigênio aos Raios X: Diferentes Abordagens da Nanotecnologia para o Tratamento do Câncer
• Beneficiário: Éder José Guidelli
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 21/00786-0 - Desenvolvimento de nanodispositivos teranósticos com propriedades dosimétricas para aplicações em física médica
• Beneficiário: Éder José Guidelli
• Modalidade de apoio: Auxílio à Pesquisa - Regular