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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Fructose in fetal cord blood and its relationship with maternal and 48-hour-newborn blood concentrations

Texto completo
Autor(es):
Trindade, Cleide E. P. [1] ; Barreiros, Rodrigo C. [2] ; Kurokawa, Cilmery [1] ; Bossolan, Grasiela [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ, UNESP, Botucatu Sch Med, Dept Pediat, Div Neonatol, BR-18618970 Sao Paulo - Brazil
[2] PUCSP Sorocaba, Sch Med, Dept Med Pediat, BR-18030095 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: EARLY HUMAN DEVELOPMENT; v. 87, n. 3, p. 193-197, MAR 2011.
Citações Web of Science: 13
Resumo

Background: Studies have suggested that different non-glucose sugars and sugar alcohols play a role in placental and fetal metabolism. However, the role of fructose in the fetal and newborn metabolism is unclear and studies are scarce. Aim: Our objective was to investigate the presence of fructose in umbilical cord blood in full-term gestation and its relationship with maternal and 48-hour-old- newborn blood concentrations, to evaluate fructose production by the fetus and newborn infant. Methods: Blood fructose and glucose concentrations were determined by HPLC in 26 paired samples of maternal blood, umbilical cord vein, and peripheral newborn blood at 48 h after birth. ANOVA, the Friedman Analysis of variance on Ranks and the Pearson correlation with p<0.05 were used. Results: Fructose concentration in umbilical cord blood was higher than maternal blood (p = 0.024), suggesting endogenous fructose production by the fetal-placental unit via the sorbitol pathway. Fructose concentrations were higher in newborns at 48 h after birth than in the fetal umbilical cord blood (p = 0.004), suggesting that fructose production is a continuous process from fetus to newborn. Conclusions: Fructose production by the sorbitol pathway, present in the fetus and newborn, is an alternative pathway in glucose metabolism probably used to maintain redox balance in the fetus. We suggest that endogenous fructose, similar to dietary ingested fructose, under physiological conditions produces the backbone for triacylglycerol and lipid synthesis in the fetus and newborn. Therefore the route for metabolizing fructose is already present in the early steps of human development. (C) 2010 Elsevier Ireland Ltd. All rights reserved. (AU)

Processo FAPESP: 95/06906-1 - Complemento da infra-estrutura do Laboratório de Investigação Clínica e Experimental do Departamento de Pediatria
Beneficiário:Cleide Enoir Petean Trindade
Modalidade de apoio: Auxílio à Pesquisa - Programa Infraestrutura - Gerais
Processo FAPESP: 95/05169-3 - Modernização e ampliação do Laboratório de Pesquisa Clínica e Experimental do Departamento de Pediatria: introdução de novas tecnologias e novas linhas de pesquisa em metabolismo e nutrição
Beneficiário:Cleide Enoir Petean Trindade
Modalidade de apoio: Auxílio à Pesquisa - Programa Infraestrutura - Gerais