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Venturini, Ana Claudia Rossini ; Fogagnolo, Caroline ; Ortiz, Gabriela Ueta ; Rodrigues, Guilherme da Silva ; da Silva, Arthur Polveiro ; Noronha, Natalia Yumi ; Abud, Gabriela Ferreira ; Silva, Bianca Monteiro ; Benzoni, Gabriela Geraldo ; Pinhel, Marcela Augusta de Souza ; Watanabe, Ligia Moriguchi ; Sae-Lee, Chanachai ; Travieso, Sofia Germano ; Viliod, Marcela Coffacci de Lima ; Nonino, Carla Barbosa ; da Silva, Adelino Sanchez Ramos ; de Freitas, Ellen Cristini

• Tipo de documento: Artigo Científico
• Fonte: Epigenomics; v. N/A, p. 15-pg., 2026-01-25.

Resumo

BackgroundSarcopenic obesity (SO), defined as the coexistence of excess fat mass and low muscle mass/function, has been linked to adverse outcomes. Epigenetic alterations are central hallmarks of aging. Evaluating how obesity, sarcopenia, and SO are related to epigenetic aging biomarkers may provide insights into cellular aging and disease risk.MethodsIn this cross-sectional study, 30 older women were classified into the control, obesity, sarcopenia, and SO groups and underwent anthropometry measurements, body composition analysis, and handgrip strength. Blood DNA methylation (DNAm) biomarkers were used to estimate eight epigenetic clocks (Horvath, Hannum, DNAmTL, PhenoAge, GrimAge, GrimAge2, Zhang, and FitAge) and to calculate intrinsic and extrinsic epigenetic age acceleration (IEAA and EEAA). Associations were tested with Bayesian linear and quantile regressions, adjusted for age and HOMA-IR.ResultsSO was associated with higher EEAA, DNAmFitAge, and Hannum clock estimates, and shorter DNAmTL in both models. Obesity showed positive associations with these clocks in adjusted models and higher quantiles.ConclusionsSO is associated with accelerated aging and shorter DNAmTL. Obesity contributes to biological aging, whereas sarcopenia without obesity does not. These findings suggest that excess adiposity combined with low muscle mass may worsen age-related decline, although the small sample size should be considered. (AU)

• Processo FAPESP: 19/11820-5 - Função do Nr1d1 sobre a Sarcopenia associada ao envelhecimento
• Beneficiário: Adelino Sanchez Ramos da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 23/09554-0 - Avaliação do padrão de metilação de dna em idosas saudáveis, sarcopênica, obesas e com obesidade sarcopênica: um estudo transversal
• Beneficiário: Ana Claudia Rossini Venturini
• Modalidade de apoio: Bolsas no Brasil - Programa Fixação de Jovens Doutores
• Processo FAPESP: 23/01611-5 - Avaliação do padrão de metilação de dna em idosas saudáveis, sarcopênica, obesas e com obesidade sarcopênica: um estudo transversal
• Beneficiário: Ellen Cristini de Freitas
• Modalidade de apoio: Auxílio à Pesquisa - Regular