| Texto completo | |
| Autor(es): Mostrar menos - |
Franca, Danielle Cristina Honorio
;
Franca, Eduardo Luzia
;
Honorio-Franca, Adenilda Cristina
;
Silva, Kenia Maria Rezende
;
Queiroz, Adriele Ataides De
;
Morais, Tassiane Cristina
;
Franca, Emanuelle Carolina Honorio
;
de Carvalho, Carolina Neiva Frota
;
Fagundes-Triches, Danny Laura Gomes
;
Barbosa, Angelica Mercia Pascon
;
Calderon, Iracema De Mattos Paranhos
;
Sobrevia, Luis
;
Rudge, Marilza Vieira Cunha
Número total de Autores: 13
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| Tipo de documento: | Artigo Científico |
| Fonte: | METABOLITES; v. 15, n. 11, p. 16-pg., 2025-10-28. |
| Resumo | |
Background: The pathogenesis of developing gestational diabetes mellitus (GDM) integrated with pregnancy-specific urinary incontinence (PSUI) may be related to immunological and hormonal factors. Inflammatory cytokines influence the function and regulation of the urinary tract, and changes in melatonin concentration are a predisposing factor for smooth muscle dysfunction and cystometric changes. Objective: This study examines the influence of melatonin, MT1 and MT2 receptors, and inflammatory cytokines in the blood and urine of pregnant women with GDM and PSUI. Methods: Two hundred sixty-nine pregnant women were approached during the diagnostic investigation of GDM and answered a specifically structured questionnaire about the involuntary loss of urine. According to these criteria, mothers were divided into four groups: continent normoglycemic (NG-C), incontinent normoglycemic (NG-I), continent GDM (GDM-C), and incontinent GDM (GDM-UI). Blood and urine samples were collected to determine the levels of melatonin, melatonin sulfate, melatonin receptors (MT1 and MT2), and inflammatory cytokines. Results: Blood level of melatonin and IL-10 was lower, but MT1, MT2, IL-1 beta, IL-8, and TNF-alpha were higher in GDM-UI compared with the NG-C group. The melatonin sulfate level was lower in the urine of the GDM-UI group compared with the NG-C group. Conclusions: Maternal hyperglycemia associated with urinary incontinence generates an inflammatory environment characterized by reduced melatonin and IL-10 and increased IL-1 beta, IL-8, and TNF-alpha in the blood of mothers with GDM with UI. This environmental condition may be involved in the pathogenesis of these pathologies. (AU) | |
| Processo FAPESP: | 16/01743-5 - Coorte da tríade gestacional: hiperglicemia, incontinência urinária e perfil clínico, molecular e ômico da miopatia hiperglicêmica na predição de incontinência e disfunção muscular e pesquisa translacional com biodevice para regeneração muscular em ratas |
| Beneficiário: | Marilza Vieira Cunha Rudge |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |