| Texto completo | |
| Autor(es): |
da Silva, Rafael Andre
;
Howell, Anna
;
Jones-Graham, Kendra
;
Parween, Shama
;
Girol, Ana Paula
;
Farsky, Sandra H. P.
;
Gil, Cristiane D.
;
Vergara, M. Natalia
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | DRUG DISCOVERY TODAY; v. 30, n. 12, p. 12-pg., 2025-12-01. |
| Resumo | |
Formyl peptide receptors (FPRs) belong to the G protein-coupled receptor family and are involved in regulating inflammatory processes, neuronal survival, and angiogenesis. In tissues such as the retina and cornea, chronic or unresolved inflammation contributes to vision loss. We review FPR2's dual, stage-dependent roles in ocular diseases, where activation by pro-resolving agonists or inhibition by antagonists can each confer therapeutic benefits. This context-specific 'on/off' potential highlights the need for precise, stage-tailored modulation. Preclinical studies demonstrate that targeting FPR2 can improve outcomes in diabetic retinopathy, keratitis, choroidal and corneal neovascularization, and reepithelialization. We also examine the molecular mechanisms, signaling pathways, and ligand specificity that drive these divergent effects, positioning FPR2 as a promising yet complex therapeutic target in ophthalmology. (AU) | |
| Processo FAPESP: | 22/12027-0 - Proteína anexina a1 na inflamação da retinopatia diabética |
| Beneficiário: | Rafael André da Silva |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 24/04275-9 - Proteína Anexina A1 na retinogênese e estresse oxidativo: Estudo em organoides retinianos derivados de iPSCs humanas |
| Beneficiário: | Rafael André da Silva |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |