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From dust to dose: How to use alanine/Electron Spin Resonance dosimetry in quality assurance in blood irradiation and radiotherapy

Texto completo
Autor(es):
Travagin, Pedro Cadamuro ; Nicolucci, Patricia ; Viccari, Cassiana ; Baffa, Oswaldo
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: Applied Radiation and Isotopes; v. 229, p. 7-pg., 2026-03-01.
Resumo

Ionizing radiation plays a fundamental role in healthcare, being used in medical diagnosis, treatment, and other non-clinical applications. Quality control is essential to ensure the correct administration of radiation doses and minimize risks. It should be carried out through independent internal and external audits, such as postal dosimetry. This study aimed to develop a practical and cost-effective dosimetry system using Electron Spin Resonance (ESR) with alanine, a versatile dosimeter for high-dose applications. Dosimeters were fabricated from a mixture of 90 % L-alanine powder and 10 % of Teflon (R), compacted into cylindrical pellets. A 3D-printed cylindrical phantom was designed to accommodate the dosimeters and simulate irradiation conditions for a blood irradiator model (Gammacell 3000) and a radiotherapy treatment. Calibration was performed using a Cesium-137 irradiator and a clinical linear accelerator. Through pilot tests, the phantom successfully allowed to obtained a dose map produced by the blood irradiator, ensuring compliance with regulatory limits for blood irradiation. For radiotherapy, the dosimetry system effectively evaluated the dose delivery in low-dose gradient regions with less than 5 % deviation, but showed limitations in high-gradient areas, reaching nearly 30 % deviation. The 3D-printed phantom proved to be a practical, adaptable, and cost-effective tool for quality control in irradiation procedures, with potential application in postal dosimetry. (AU)

Processo FAPESP: 13/07699-0 - Centro de Pesquisa, Inovação e Difusão em Neuromatemática - NeuroMat
Beneficiário:Oswaldo Baffa Filho
Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 25/26818-7 - Pesquisas Inovadoras em Ciências da Saúde: da Nanotecnologia à Inteligência Artificial - INCT PICS
Beneficiário:Oswaldo Baffa Filho
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 18/05982-0 - P&D&I em metrologia das radiações na área da saúde
Beneficiário:Linda Viola Ehlin Caldas
Modalidade de apoio: Auxílio à Pesquisa - Temático