| Texto completo | |
| Autor(es): |
Okamoto-Schalch, Nadia Obrownick
;
Pereira, Ricardo N.
;
Vicente, Antonio A.
;
de Carvalho, Rosemary Aparecida
;
Sobral, Paulo Jose do Amaral
;
Martelli-Tosi, Milena
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NEXT MATERIALS; v. 10, p. 9-pg., 2026-01-01. |
| Resumo | |
The objective of this study was to produce chitosan cryogels and investigate the effect of the incorporation of nanocellulose, liposome or chitosome hybrid systems loaded with propolis extract (PE) on their physicochemical properties and in vitro mucoadhesivenes. PE was loaded in liposomes uncoated (L) or coated with chitosan without (chitosomes - Ch) or with crosslinking by using sodium tripolyphosphate (TPPCh). Soybean pod nanocelluloses (CNs) were produced and added to the hybrid particles, obtaining CN-L, CN-Ch and CN-TPPCh. Cryogels containing 3 wt% nanocellulose and TPP-crosslinked chitosomes displayed a mucoadhesive force of 0.2 +/- 0.1 N, 1.6-fold higher than controls. Cryogel pore sizes ranged from 10 to 100 mu m, larger in liposome-only samples, explaining their higher fragility, being unsuitable for further characterizations. Nanocellulose addition exhibited smaller pores due to fiber network formation and lower wettability for L samples (water contact angle WCA = 84.1 degrees at 15 s). TPPCh showed pores more filled, influenced by ionic gelation, and have shown a higher WCA (up to 110 degrees at 15 s). The addition of Ch and TPPCh has significantly improved the hydrophobicity of the chitosan-based cryogels. However, only CN-L and CN-TPPCh revealed enhanced properties of mucoadhesiviness, highlighting the importance of the incorporation of nanocellulsoes into these matrices. Therefore, hybrid systems composed of nanocelluloses and TPP-chitosomes emerge as interesting particles to improve cryogel properties for bioactive delivery applications. (AU) | |
| Processo FAPESP: | 19/23171-1 - Aproveitamento de subprodutos obtidos após processamento de alimentos: extração de compostos fitoquímicos, encapsulação e aplicação em filmes / coberturas biodegradáveis |
| Beneficiário: | Milena Martelli Tosi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 22/03469-9 - Produção de partículas carregadas e de nanoceluloses a partir de subprodutos agroindustriais: aplicação potencial em coberturas ativas ou filmes de PLA |
| Beneficiário: | Milena Martelli Tosi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |