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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Contrast Sensitivity Mediated by Inferred Magno- and Parvocellular Pathways in Type 2 Diabetics with and without Nonproliferative Retinopathy

Texto completo
Autor(es):
Gualtieri, Mirella [1] ; Bandeira, Marcio [1] ; Hamer, Russell David [2, 1] ; Damico, Francisco Max [1, 3] ; Araujo Moura, Ana Laura [1] ; Ventura, Dora Fix [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Psicol, Dept Psicol Expt, BR-05508030 Sao Paulo - Brazil
[2] Smith Kettlewell Eye Res Inst, San Francisco, CA 94115 - USA
[3] Univ Sao Paulo, Dept Oftalmol, Fac Med, BR-05508030 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE; v. 52, n. 2, p. 1151-1155, FEB 2011.
Citações Web of Science: 18
Resumo

PURPOSE. To evaluate achromatic contrast sensitivity (CS) with magnocellular-(M) and parvocellular-(P) probing stimuli in type 2 diabetics, with (DR) or without (NDR) nonproliferative retinopathy. METHODS. Inferred M-and P-dominated responses were assessed with a modified version of the steady-/pulsed-pedestal paradigm (SP/PP) applied in 26 NDR (11 male; mean age, 55 +/- 9 years; disease duration, 5 +/- 4 years); 19 DR (6 male; mean age, 58 +/- 7 years; disease duration = 9 +/- 6 years); and 18 controls (CTRL; 12 male; mean age, 55 +/- 10 years). Thresholds were measured with pedestals at 7, 12, and 19 cd/m(2), and increment durations of 17 and 133 ms. The thresholds from the two stimulus durations were used to estimate critical durations (Tc) for each data set. RESULTS. Both DR and NDR patients had significant reduction in CS in both SP and PP paradigms in relation to CTRL (Kruskal-Wallis, P < 0.01). Patients' critical duration estimates for either paradigm were not significantly different from CTRL. CONCLUSIONS. The significant reduction of CS in both paradigms is consistent with losses of CS in both M and P pathways. The CS losses were not accompanied by losses in temporal processing speed in either diabetic group. Significant CS loss in the group without retinopathy reinforces the notion that neural changes associated with the cellular and functional visual loss may play an important role in the etiology of diabetic visual impairment. In addition, the results show that the SP/PP paradigm provides an additional tool for detection and characterization of the early functional damage due to diabetes. (Invest Ophthalmol Vis Sci. 2011; 52:1151-1155) DOI:10.1167/iovs.09-3705 (AU)

Processo FAPESP: 04/15926-7 - Avaliação visual longitudinal de pacientes diabéticos em estados pré e pós retinopatia diabética
Beneficiário:Mirella Gualtieri
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 02/12733-8 - Perdas sensoriais causadas pela intoxicação mercurial: estudos psicofísicos e neurofisiológicos em pacientes e em modelos animais
Beneficiário:Dora Selma Fix Ventura
Linha de fomento: Auxílio à Pesquisa - Temático