Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association

Autor(es)

Donadi, Eduardo A. ^[1] ; Castelli, Erick C. ^[1] ; Arnaiz-Villena, Antonio ^[2] ; Roger, Michel ^[3] ; Rey, Diego ^[2] ; Moreau, Philippe ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Div Clin Immunol, Dept Med, Sch Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Complutense, Dept Immunol, Madrid Reg Blood Ctr, E-28040 Madrid - Spain

^[3] Ctr Hosp Univ Montreal, Ctr Rech, Immunogenet Lab, Montreal, PQ - Canada

^[4] Hop St Louis, Commissariat Energie Atom, Serv Rech Hematoimmunol, IUH, DSV, I2BM, F-75010 Paris - France

• Tipo de documento: Artigo de Revisão
• Fonte: CELLULAR AND MOLECULAR LIFE SCIENCES; v. 68, n. 3, p. 369-395, FEB 2011.
• Citações Web of Science: 165

Resumo

The HLA-G gene displays several peculiarities that are distinct from those of classical HLA class I genes. The unique structure of the HLA-G molecule permits a restricted peptide presentation and allows the modulation of the cells of the immune system. Although polymorphic sites may potentially influence all biological functions of HLA-G, those present at the promoter and 3' untranslated regions have been particularly studied in experimental and pathological conditions. The relatively low polymorphism observed in the MHC-G coding region both in humans and apes may represent a strong selective pressure for invariance, whereas, in regulatory regions several lines of evidence support the role of balancing selection. Since HLA-G has immunomodulatory properties, the understanding of gene regulation and the role of polymorphic sites on gene function may permit an individualized approach for the future use of HLA-G for therapeutic purposes. (AU)

• Processo FAPESP: 07/58420-4 - Polimorfismos da região promotora e expressão de HLA-G em pacientes com histórico de carcinoma de células transicionais da bexiga urinária
• Beneficiário: Erick da Cruz Castelli
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado