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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association

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Author(s):
Donadi, Eduardo A. [1] ; Castelli, Erick C. [1] ; Arnaiz-Villena, Antonio [2] ; Roger, Michel [3] ; Rey, Diego [2] ; Moreau, Philippe [4]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Div Clin Immunol, Dept Med, Sch Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Complutense, Dept Immunol, Madrid Reg Blood Ctr, E-28040 Madrid - Spain
[3] Ctr Hosp Univ Montreal, Ctr Rech, Immunogenet Lab, Montreal, PQ - Canada
[4] Hop St Louis, Commissariat Energie Atom, Serv Rech Hematoimmunol, IUH, DSV, I2BM, F-75010 Paris - France
Total Affiliations: 4
Document type: Review article
Source: CELLULAR AND MOLECULAR LIFE SCIENCES; v. 68, n. 3, p. 369-395, FEB 2011.
Web of Science Citations: 165
Abstract

The HLA-G gene displays several peculiarities that are distinct from those of classical HLA class I genes. The unique structure of the HLA-G molecule permits a restricted peptide presentation and allows the modulation of the cells of the immune system. Although polymorphic sites may potentially influence all biological functions of HLA-G, those present at the promoter and 3' untranslated regions have been particularly studied in experimental and pathological conditions. The relatively low polymorphism observed in the MHC-G coding region both in humans and apes may represent a strong selective pressure for invariance, whereas, in regulatory regions several lines of evidence support the role of balancing selection. Since HLA-G has immunomodulatory properties, the understanding of gene regulation and the role of polymorphic sites on gene function may permit an individualized approach for the future use of HLA-G for therapeutic purposes. (AU)