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Identification of SNPs in CpG sites located in genomic regions related to production in cattle

Grant number: 15/20557-5
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2015
Effective date (End): August 31, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Flavia Lombardi Lopes
Grantee:Mariângela Bueno Cordeiro Maldonado
Host Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil
Associated scholarship(s):16/07584-6 - Phenotypic effects of mutations in regulatory regions of the genome in cattle, BE.EP.DR


DNA methylation is an important epigenetic modification in many cellular processes, playing an important role as regulator of gene expression. Recent studies show the broad association between methylation levels and gene expression variation. However, the association between genetic variation and DNA methylation, as well as the genetic determinants of DNA methylation patterns are still unclear. Genetic variations in CpG sites can disrupt methylation sites and thus dramatically change the methylation state. The introduction or removal of a CpG site, that are likely sites of DNA methylation, has been suggested as a potential mechanism by which single nucleotide polymorphisms (SNPs) can affect gene function via epigenetic changes. Polymorphisms in regions controlled by methylation can alter the epigenetic regulation of the region, and can also result in a change in gene expression. The project aims to identify single nucleotide polymorphisms subject to the epigenetic control of DNA methylation in CpG sites (meSNPs), as well as to determine its possible association with the methylation profile of production-related genes in cattle. The results will be important for further use in association studies between different bovine breeds, for example, to identify genes associated with disease susceptibility, development or performance.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MALDONADO, MARIANGELA B. C.; DE REZENDE NETO, NELSON B.; NAGAMATSU, SHEILA T.; CARAZZOLLE, MARCELO F.; HOFF, JESSE L.; WHITACRE, LYNSEY K.; SCHNABEL, ROBERT D.; BEHURA, SUSANTA K.; MCKAY, STEPHANIE D.; TAYLOR, JEREMY F.; et al. Identification of bovine CpG SNPs as potential targets for epigenetic regulation via DNA methylation. PLoS One, v. 14, n. 9, . (15/20557-5, 16/07584-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MALDONADO, Mariângela Bueno Cordeiro. Identification of SNPs in CpG sites located in genomic regions related to production in cattle. 2017. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária. Araçatuba Araçatuba.

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