Identification of copy number variations in Girolando cattle

• Grant number: 15/08939-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): July 01, 2015
• Effective date (End): February 28, 2018
• Field of knowledge: Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
• Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Danísio Prado Munari
• Grantee: Tatiane Cristina Seleguim Chud
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

The advances in genomic technologies allowed the identification of the structural variations in the genome of humans and domestic animals, such as copy number variation (CNV). The CNV have been observed as an important source of genetic and phenotypic variation for production traits and animal health. The aim of this work will be to identify regions of copy number variation in the genome of Girolando cattle and to associate these regions with milk production trait. The data set from Embrapa Dairy Cattle, Juiz de Fora, MG, will be contained 470 animals genotyped with Illumina BovineSNP50 panel (54,609 SNP), 200 animals genotyped with BovineHD Illumina BeadChip panel (786,799 SNP) and 3 animals with whole genome sequence. The analyses for CNV identification will perform using PennCNV software and RAPTR-SV. After CNVR identification, the association studies with milk production trait will be conducted and these regions will be validated by real-time PCR. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OLIVEIRA JUNIOR, GERSON A.; CHUD, TATIANE C. S.; VENTURA, RICARDO V.; GARRICK, DORIAN J.; COLE, JOHN B.; MUNARI, DANISIO P.; FERRAZ, JOSE B. S.; MULLART, ERIK; DENISE, SUE; SMITH, SHANNON; et al. Genotype imputation in a tropical crossbred dairy cattle population. JOURNAL OF DAIRY SCIENCE, v. 100, n. 12, p. 9623-9634, DEC 2017. (13/12097-9, 15/08939-0)

BUZANSKAS, MARCOS ELI; GROSSI, DANIELA DO AMARAL; VENTURA, RICARDO VIEIRA; SCHENKEL, FLAVIO SCHRAMM; SELEGUIM CHUD, TATIANE CRISTINA; STAFUZZA, NEDENIA BONVINO; ROLA, LUCIANA DINIZ; CONCEICAO MEIRELLES, SARAH LAGUNA; MOKRY, FABIANA BARICHELLO; MUDADU, MAURICIO DE ALVARENGA; et al. Candidate genes for male and female reproductive traits in Canchim beef cattle. JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY, v. 8, AUG 23 2017. (13/13972-0, 15/08939-0)

BUZANSKAS, MARCOS ELI; VENTURA, RICARDO VIEIRA; SELEGUIM CHUD, TATIANE CRISTINA; BERNARDES, PRISCILA ARRIGUCCI; DE ABREU SANTOS, DANIEL JORDAN; DE ALMEIDA REGITANO, LUCIANA CORREIA; DE ALENCAR, MAURICIO MELLO; MUDADU, MAURICIO DE ALVARENGA; ZANELLA, RICARDO; GUALBERTO BARBOSA DA SILVA, MARCOS VINICIUS; et al. Study on the introgression of beef breeds in Canchim cattle using single nucleotide polymorphism markers. PLoS One, v. 12, n. 2, FEB 9 2017. (12/23638-8, 15/12396-1, 15/08939-0, 13/19335-2, 15/25096-6)

BUZANSKAS, M. E.; PIRES, P. S.; CHUD, T. C. S.; BERNARDES, P. A.; ROLA, L. D.; SAVEGNAGO, R. P.; LOBO, R. B.; MUNARI, D. P.. Parameter estimates for reproductive and carcass traits in Nelore beef cattle. Theriogenology, v. 92, p. 204-209, APR 1 2017. (13/20091-0, 15/08939-0, 13/13972-0, 13/19335-2, 15/25096-6)

STAFUZZA, NEDENIA BONVINO; ZERLOTINI, ADHEMAR; LOBO, FRANCISCO PEREIRA; BELEZA YAMAGISHI, MICHEL EDUARDO; SELEGUIM CHUD, TATIANE CRISTINA; CAETANO, ALEXANDRE RODRIGUES; MUNARI, DANISIO PRADO; GARRICK, DORIAN J.; MACHADO, MARCO ANTONIO; MARTINS, MARTA FONSECA; et al. Single nucleotide variants and InDels identified from whole-genome re-sequencing of Guzerat, Gyr, Girolando and Holstein cattle breeds. PLoS One, v. 12, n. 3, MAR 21 2017. (15/08939-0)

GROSSI, DANIELA DO AMARAL; BERTON, MARIANA PIATTO; BUZANSKAS, MARCOS ELI; SELEGUIM CHUD, TATIANE CRISTINA; GRUPIONI, NATALIA VINHAL; PARO DE PAZ, CLAUDIA CRISTINA; LOBO, RAYSILDO BARBOSA; MUNARI, DANISIO PRADO. Genetic analysis on accumulated productivity and calving intervals in Nelore cattle. TROPICAL ANIMAL HEALTH AND PRODUCTION, v. 48, n. 1, p. 207-210, JAN 2016. (13/19335-2, 15/08939-0)

URBINATI, ISMAEL; STAFUZZA, NEDENIA BONVINO; OLIVEIRA, MARCOS TULIO; SELEGUIM CHUD, TATIANE CRISTINA; HIGA, ROBERTO HIROSHI; DE ALMEIDA REGITANO, LUCIANA CORREIA; DE ALENCAR, MAURICIO MELLO; BUZANSKAS, MARCOS ELI; MUNARI, DANISIO PRADO. Selection signatures in Canchim beef cattle. JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY, v. 7, MAY 5 2016. (13/09050-0, 13/19335-2, 14/02253-6, 15/08939-0)

JOAQUIM, LETICIA BORGES; SELEGUIM CHUD, TATIANE CRISTINA; PETROLI MARCHESI, JORGE AUGUSTO; SAVEGNAGO, RODRIGO PELICIONI; BUZANSKAS, MARCOS ELI; ZANELLA, RICARDO; CANTAO, MAURICIO EGIDIO; PEIXOTO, JANE OLIVEIRA; LEDUR, MONICA CORREA; IRGANG, RENATO; et al. Genomic structure of a crossbred Landrace pig population. PLoS One, v. 14, n. 2, FEB 28 2019. (15/08939-0, 13/20091-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CHUD, Tatiane Cristina Seleguim. Copy number variation discovery in dairy cattle. 2018. Doctoral Thesis - Universidade Estadual Paulista (Unesp).