The Protective Role of Lychnophora ericoides Mart. (Brazilian Arnica) in 1,2-Dimethylhydrazine-Induced Experimental Colon Carcinogenesis

Autor(es)

Fernandes, Cleverson Rodrigues ^[1] ; Turatti, Aline ^[1] ; Gouvea, Dayana Rubio ^[2] ; Gobbo-Neto, Leonardo ^[2] ; Diniz, Andrea ^[2] ; Ribeiro-Silva, Alfredo ^[1] ; Lopes, Norberto Peporine ^[2] ; Garcia, Sergio Britto ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Pathol, Ribeirao Preto Med Sch, Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, Dept Chem & Phys, Fac Pharmaceut Sci, Ribeirao Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL; v. 63, n. 4, p. 593-599, 2011.
• Citações Web of Science: 7

Resumo

Aberrant crypt foci (ACF) and colon rectal mucosal epithelial cell proliferation have been shown to be increased in patients with colon cancer and have been largely used for early detection of factors that influence colorectal carcinogenesis in rats. Fifty male Wistar rats were randomly divided into 5 groups. The groups G1 to G4 were given 4 injections of the carcinogen 1,2-dimethylhydrazine (DMH). The G2 group received Lychnophora ericoides (LE) extracts for 6 wk. The groups G3 and G4 received LE for 4 wk and 2 wk, respectively, at the postinitiation and initiation phases of colonic carcinogenesis. The group G5 was the control. Forty-two days after the first injections of DMH for the neoplasic induction, we observed a statistically significant decrease in the number of aberrant crypt foci (ACF) and an attenuation of the increase in cell proliferation induced by DMH in all the LE-treated groups. Thus, we concluded that Lychnophora ericoides extracts were effective against the development of cancer. These data suggest that LE has a protective influence on the process of colon carcinogenesis, suppressing both the initiation and the promotion of colonic carcinogenesis. (AU)

• Processo FAPESP: 01/14227-0 - Estudo da incidência, morfologia, alterações do gene APC e instabilidade de microsatélites nos focos de criptas aberrantes induzidos por dimetilhidrazina no megacólon experimental em ratos
• Beneficiário: Sérgio Britto Garcia
• Modalidade de apoio: Auxílio à Pesquisa - Regular