Cumulative Coffee Consumption and Reduced Risk of Oral and Oropharyngeal Cancer

Autor(es)

Haye Biazevic, Maria Gabriela ^[1] ; Toporcov, Tatiana Natasha ^[2] ; Ferreira Antunes, Jose Leopoldo ^[2] ; Braga Rotundo, Ligia Drovandi ^[1] ; Brasileiro, Rosana Sarmento ^[3] ; de Carvalho, Marcos Brasilino ^[3] ; de Gois Filho, Jose Francisco ^[4] ; Kowalski, Luiz Paulo ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Odontol, BR-01246904 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Saude Publ, BR-01246904 Sao Paulo - Brazil

^[3] Hosp Heliopolis, Sao Paulo - Brazil

^[4] Inst Canc Arnaldo Vieira de Carvalho, Sao Paulo - Brazil

^[5] Hosp AC Camargo Fund Antonio Prudente, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL; v. 63, n. 3, p. 350-356, 2011.
• Citações Web of Science: 5

Resumo

We examined the association between coffee consumption and oral cancer in a hospital-based case-control study comprising 143 patients with oral and oropharyngeal squamous cell carcinoma attended at 3 major hospitals in Sao Paulo, Brazil, and 240 controls without cancer, recruited from outpatient units of the same hospitals and matched with cases by sex and age. Associations were assessed by multivariate logistic regression conditioned on sociodemographic and behavioral characteristics. Tobacco smoking, alcohol drinking, and higher intake of bacon and deep-fried foods were directly related to disease; the inverse was observed to family income and salad intake. Coffee consumption and tobacco smoking were partially correlated (Spearman correlation coefficient 0.14 among cases, 0.31 among controls). When adjusted for all covariates, a cumulative coffee consumption higher than 18.0 daily liters x year during lifetime was indicated to be protective against disease (adjusted odds ratio 0.39, 95% confidence interval 0.16-0.94, P = 0.037). This observation may have pharmacological implications for clinical medication of these cancers and is relevant to programs aimed at reducing the burden of disease. (AU)

• Processo FAPESP: 06/01238-7 - Qualidade de vida de pacientes com câncer de boca e orofaringe do Projeto Genoma Clínico
• Beneficiário: Maria Gabriela Haye Biazevic
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 06/58229-0 - Habitos alimentares e cancer de boca e orofaringe.
• Beneficiário: Tatiana Natasha Toporcov
• Modalidade de apoio: Bolsas no Brasil - Mestrado