Palladium(II) complex with S-allyl-L-cysteine: New solid-state NMR spectroscopic measurements, molecular modeling and antibacterial assays

Autor(es)

Spera, Marcelle B. M. ^[1] ; Quintao, Frederico A. ^[2] ; Ferraresi, Diego K. D. ^[2] ; Lustri, Wilton R. ^[2] ; Magalhaes, Alvicler ^[1] ; Formiga, Andre L. B. ^[1] ; Corbi, Pedro P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Quim, UNICAMP, BR-13083970 Campinas, SP - Brazil

^[2] Ctr Univ Araraquara UNIARA, Dept Ciencias Biol & Saude, Assoc Sao Bento de Ensino, BR-14801320 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY; v. 78, n. 1, p. 313-318, JAN 2011.
• Citações Web of Science: 13

Resumo

Nuclear magnetic resonance studies, molecular modeling and antibacterial assays of the palladium(II) complex with S-allyl-L-cysteine (deoxyalliin) are presented. Studies based on solid and solution (13)C and (15)N nuclear magnetic resonance (NMR) spectroscopy confirmed that the palladium(II) complex preserved the same structural arrangement in both states, with no modifications on coordination sphere when dissolved in water. Density functional theory (DFT) studies stated that the trans isomer is the most stable one. Antibacterial activities of S-allyl-L-cysteine and its palladium(II) complex were evaluated by antibiogram assays using the disc diffusion method. The palladium(II) complex showed an effective antibacterial activity against Staphylococcus aureus (Gram-positive), Escherichia coli and Pseudomonas aeruginosa (Gram-negative) bacterial cells. (C) 2010 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 06/55367-2 - Complexos metálicos de platina (II), platina (IV), paládio (II), ouro (I) e ouro (III) com aminoácidos e derivados: síntese, caracterização e aplicações farmacológicas
• Beneficiário: Pedro Paulo Corbi
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores