Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease

Autor(es)

Cardoso-Lopes, Elaine Monteiro ^[1] ; Maier, James Andreas ^[1] ; da Silva, Marcelo Rogerio ^[1] ; Ragasini, Luis Octavio ^[2] ; Simote, Simone Yasue ^[2] ; Lopes, Norberto Peporine ^[3] ; Pirani, Jose Rubens ^[4] ; Bolzani, Vanderlan da Silva ^[2] ; Marx Young, Maria Claudia ^[1]

Afiliação do(s) autor(es)

^[1] Inst Bot, Sect Plant Physiol & Biochem, BR-01061970 Sao Paulo - Brazil

^[2] Sao Paulo State Univ, Inst Chem, BR-14801970 Araraquara, SP - Brazil

^[3] Univ Sao Paulo, Dept Chem & Phys, BR-14040903 Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Dept Bot, Biosci Inst, BR-05422970 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Molecules; v. 15, n. 12, p. 9205-9213, DEC 2010.
• Citações Web of Science: 30

Resumo

Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guaranta, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC(50) = 2.5 mu M), similar to that of the reference compound galanthamine (IC(50) = 1.7 mu M). The results showed for the first time the presence of alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity. (AU)

• Processo FAPESP: 03/02176-7 - Conservação e uso sustentável da diversidade do Cerrado e da Mata Atlântica: diversidade química e prospecção de medicamentos potenciais - fase II
• Beneficiário: Vanderlan da Silva Bolzani
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático