Sesquiterpenes from Xylaria sp., an endophytic fungus associated with Piper aduncum (Piperaceae)

Autor(es):Mostrar menos -

Silva, Geraldo H. ^[1] ; de Oliveira, Camila M. ^[2] ; Teles, Helder L. ^[3] ; Pauletti, Patricia M. ^[4] ; Castro-Gamboa, Ian ^[2] ; Silva, Dulce H. S. ^[2] ; Bolzani, Vanderlan S. ^[2] ; Young, Maria C. M. ^[5] ; Costa-Neto, Claudio M. ^[6] ; Pfenning, Ludwig H. ^[7] ; Berlinck, Roberto G. S. ^[8] ; Araujo, Angela R. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sergipe, Dept Quim, BR-49500000 Itabaiana, SE - Brazil

^[2] Univ Estadual Paulista, Inst Quim, NuBBE Nucleo Bioensaios Biossintese & Ecofisiol P, BR-14800900 Araraquara, SP - Brazil

^[3] Univ Fed Mato Grosso, Dept Ciencias Biol, BR-78735901 Rondonopolis, MT - Brazil

^[4] Univ Franca, BR-13570050 Sao Paulo - Brazil

^[5] Inst Bot, Seccao Fisiol & Bioquim Plantas, BR-01061970 Sao Paulo - Brazil

^[6] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, BR-14049900 Ribeirao Preto, SP - Brazil

^[7] Univ Fed Lavras, Dept Fitopatol, BR-37200000 Lavras, MG - Brazil

^[8] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PHYTOCHEMISTRY LETTERS; v. 3, n. 3, p. 164-167, SEP 20 2010.
• Citações Web of Science: 31

Resumo

Two new presilphiperfolane sesquiterpenes, 1 and 2, were isolated from the ethyl acetate extract of Xylaria sp., obtained from the leaves of Piper aduncum, along with two known eremophilane sesquiterpenes, phaseolinone (3) and phomenone (4). Chemical structures of 1 and 2 were established by analysis of spectroscopic data. The four compounds were tested in vitro for antifungal and cytotoxicity activities using CHO (Chinese hamster ovary). Compounds 1 and 2 did not show any antifungal and cytotoxic activity. Compounds 3 and 4 displayed moderate cytotoxic activities, as well as 4 antifungal activity. (C) 2010 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved. (AU)

• Processo FAPESP: 03/02176-7 - Conservação e uso sustentável da diversidade do Cerrado e da Mata Atlântica: diversidade química e prospecção de medicamentos potenciais - fase II
• Beneficiário: Vanderlan da Silva Bolzani
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático