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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sesquiterpenes from Xylaria sp., an endophytic fungus associated with Piper aduncum (Piperaceae)

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Author(s):
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Silva, Geraldo H. [1] ; de Oliveira, Camila M. [2] ; Teles, Helder L. [3] ; Pauletti, Patricia M. [4] ; Castro-Gamboa, Ian [2] ; Silva, Dulce H. S. [2] ; Bolzani, Vanderlan S. [2] ; Young, Maria C. M. [5] ; Costa-Neto, Claudio M. [6] ; Pfenning, Ludwig H. [7] ; Berlinck, Roberto G. S. [8] ; Araujo, Angela R. [2]
Total Authors: 12
Affiliation:
[1] Univ Fed Sergipe, Dept Quim, BR-49500000 Itabaiana, SE - Brazil
[2] Univ Estadual Paulista, Inst Quim, NuBBE Nucleo Bioensaios Biossintese & Ecofisiol P, BR-14800900 Araraquara, SP - Brazil
[3] Univ Fed Mato Grosso, Dept Ciencias Biol, BR-78735901 Rondonopolis, MT - Brazil
[4] Univ Franca, BR-13570050 Sao Paulo - Brazil
[5] Inst Bot, Seccao Fisiol & Bioquim Plantas, BR-01061970 Sao Paulo - Brazil
[6] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, BR-14049900 Ribeirao Preto, SP - Brazil
[7] Univ Fed Lavras, Dept Fitopatol, BR-37200000 Lavras, MG - Brazil
[8] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 8
Document type: Journal article
Source: PHYTOCHEMISTRY LETTERS; v. 3, n. 3, p. 164-167, SEP 20 2010.
Web of Science Citations: 31
Abstract

Two new presilphiperfolane sesquiterpenes, 1 and 2, were isolated from the ethyl acetate extract of Xylaria sp., obtained from the leaves of Piper aduncum, along with two known eremophilane sesquiterpenes, phaseolinone (3) and phomenone (4). Chemical structures of 1 and 2 were established by analysis of spectroscopic data. The four compounds were tested in vitro for antifungal and cytotoxicity activities using CHO (Chinese hamster ovary). Compounds 1 and 2 did not show any antifungal and cytotoxic activity. Compounds 3 and 4 displayed moderate cytotoxic activities, as well as 4 antifungal activity. (C) 2010 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved. (AU)

FAPESP's process: 03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II
Grantee:Vanderlan da Silva Bolzani
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants