Optimisation of a continuous flash fermentation for butanol production using the response surface methodology

Autor(es)

Mariano, Adriano Pinto ^[1] ; Borba Costa, Caliane Bastos ^[1] ; de Angelis, Dejanira de Franceschi ^[2] ; Maugeri Filho, Francisco ^[3] ; Pires Atala, Daniel Ibraim ^[3] ; Wolf Maciel, Maria Regina ^[1] ; Maciel Filho, Rubens ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Lab Optimizat Design & Adv Control, LOPCA Sch Chem Engn, UNICAMP, BR-13083970 Campinas, SP - Brazil

^[2] Sao Paulo State Univ, Dept Biochem & Microbiol, Inst Biosci, UNESP, BR-13506900 Rio Claro, SP - Brazil

^[3] Univ Estadual Campinas, Lab Bioproc Engn, Sch Food Engn, UNICAMP, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CHEMICAL ENGINEERING RESEARCH & DESIGN; v. 88, n. 5-6A, p. 562-571, MAY-JUN 2010.
• Citações Web of Science: 15

Resumo

Factorial design and response surface techniques were used in combination with mathematical modelling and computational simulation to optimise an innovative industrial bioprocess, the production of biobutanol employing the flash fermentation technology. A parametric analysis performed by means of a full factorial design at two levels determined the influence of operating variables on butanol yield and productivity. A second set of simulations were carried out based on the central composite rotatable design. This procedure generated simplified statistical models that describe butanol yield and productivity as functions of the significant operating variables. From these models, response surfaces were obtained and used to optimise the process. For a range of substrate concentration from 130 to 180 g/l, the optimum operating ranges ensure butanol productivity between 7.0 and 8.0 g/l h, butanol yield between 19 and 22%, substrate conversion above 90% and final butanol concentration around 25 g/l. (C) 2009 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 06/55177-9 - Estudo teórico e experimental de processos de cristalização, convencionais e para obtenção de nanopartículas: implementação do controle preditivo em cristalizadores e de políticas operacionais
• Beneficiário: Caliane Bastos Borba Costa
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 07/00341-1 - Modelagem, simulação e controle de um processo fermentativo contínuo extrativo de produção de butanol
• Beneficiário: Adriano Pinto Mariano
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado