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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Optimisation of a continuous flash fermentation for butanol production using the response surface methodology

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Mariano, Adriano Pinto [1] ; Borba Costa, Caliane Bastos [1] ; de Angelis, Dejanira de Franceschi [2] ; Maugeri Filho, Francisco [3] ; Pires Atala, Daniel Ibraim [3] ; Wolf Maciel, Maria Regina [1] ; Maciel Filho, Rubens [1]
Total Authors: 7
[1] Univ Estadual Campinas, Lab Optimizat Design & Adv Control, LOPCA Sch Chem Engn, UNICAMP, BR-13083970 Campinas, SP - Brazil
[2] Sao Paulo State Univ, Dept Biochem & Microbiol, Inst Biosci, UNESP, BR-13506900 Rio Claro, SP - Brazil
[3] Univ Estadual Campinas, Lab Bioproc Engn, Sch Food Engn, UNICAMP, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: CHEMICAL ENGINEERING RESEARCH & DESIGN; v. 88, n. 5-6A, p. 562-571, MAY-JUN 2010.
Web of Science Citations: 15

Factorial design and response surface techniques were used in combination with mathematical modelling and computational simulation to optimise an innovative industrial bioprocess, the production of biobutanol employing the flash fermentation technology. A parametric analysis performed by means of a full factorial design at two levels determined the influence of operating variables on butanol yield and productivity. A second set of simulations were carried out based on the central composite rotatable design. This procedure generated simplified statistical models that describe butanol yield and productivity as functions of the significant operating variables. From these models, response surfaces were obtained and used to optimise the process. For a range of substrate concentration from 130 to 180 g/l, the optimum operating ranges ensure butanol productivity between 7.0 and 8.0 g/l h, butanol yield between 19 and 22%, substrate conversion above 90% and final butanol concentration around 25 g/l. (C) 2009 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved. (AU)