DIFFERENTIAL PULSE VOLTAMMETRIC DETERMINATION OF SILDENAFIL CITRATE (VIAGRA (R)) IN PHARMACEUTICAL FORMULATIONS USING A BORON-DOPED DIAMOND ELECTRODE

Autor(es)

Batista, Erica Ferreira ^[1] ; Sartori, Elen Romao ^[1] ; Medeiros, Roberta Antigo ^[1] ; Rocha-Filho, Romeu C. ^[1] ; Fatibello-Filho, Orlando ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Analytical Letters; v. 43, n. 6, p. 1046-1054, 2010.
• Citações Web of Science: 38

Resumo

The determination of sildenafil citrate using differential pulse voltammetry and a cathodically pre-treated boron-doped diamond electrode is described. The obtained analytical curve is linear in the sildenafil concentration range 7.3 x 10(-7) - 7.3 x 10(-6) mol L(-1) in a 0.1 mol L(-1) H(2)SO(4), with a detection limit of 6.4 x 10(-7) mol L(-1). The proposed method, which is fast and simple to carry out, was successfully applied in the determination of sildenafil citrate in Viagra (R) pharmaceutical formulations, with results in close agreement (at 95% confidence level) with those obtained using a comparative HPLC method. (AU)

• Processo FAPESP: 07/07692-4 - Determinação Voltamétrica de Viagra (Citrato de Sildenafil) em Formulações Farmacêuticas Empregando um Eletrodo de Diamante Dopado com Boro
• Beneficiário: Érica Ferreira Batista
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica