DIFFERENTIAL PULSE VOLTAMMETRIC DETERMINATION OF SILDENAFIL CITRATE (VIAGRA (R)) IN PHARMACEUTICAL FORMULATIONS USING A BORON-DOPED DIAMOND ELECTRODE

Author(s)

Batista, Erica Ferreira ^[1] ; Sartori, Elen Romao ^[1] ; Medeiros, Roberta Antigo ^[1] ; Rocha-Filho, Romeu C. ^[1] ; Fatibello-Filho, Orlando ^[1]

Affiliation

^[1] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: Analytical Letters; v. 43, n. 6, p. 1046-1054, 2010.
• Web of Science Citations: 38

Abstract

The determination of sildenafil citrate using differential pulse voltammetry and a cathodically pre-treated boron-doped diamond electrode is described. The obtained analytical curve is linear in the sildenafil concentration range 7.3 x 10(-7) - 7.3 x 10(-6) mol L(-1) in a 0.1 mol L(-1) H(2)SO(4), with a detection limit of 6.4 x 10(-7) mol L(-1). The proposed method, which is fast and simple to carry out, was successfully applied in the determination of sildenafil citrate in Viagra (R) pharmaceutical formulations, with results in close agreement (at 95% confidence level) with those obtained using a comparative HPLC method. (AU)

• FAPESP's process: 07/07692-4 - Voltammetric Determination of Viagra (Sildenafil Citrate) in Pharmaceutical Formulations Using a Boron Doped Diamond Electrode
• Grantee: Érica Ferreira Batista
• Support Opportunities: Scholarships in Brazil - Scientific Initiation