Evaluation of Arterial Blood Pressure and Renal Sodium Handling in a Model of Female Rats in Persistent Estrus

Autor(es)

Rocha Gontijo, Jose Antonio ^[1] ; Gui, Daniela C. ^[1] ; Boer, Patricia Aline ^[1] ; Dos Santos, Alesse Ribeiro ^[2] ; Ferreira-filho, Celso Pires ^[2] ; Nery Aguiar, Afif Rieth ^[2] ; Da Silva, Benedito Borges ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Lab Hidro Saline Metab, Dept Med & Expt Surg, Sao Paulo - Brazil

^[2] Univ Fed Piaui, Dept Gynecol, Teresina, Piaui - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL AND EXPERIMENTAL HYPERTENSION; v. 32, n. 6, p. 385-389, 2010.
• Citações Web of Science: 2

Resumo

The aim of this study was to evaluate the arterial blood pressure and renal function of female rats in persistent estrus. Twenty-five female Wistar-Hannover rats were randomly divided into two groups: Group I (control, n = 15) and experimental (persistent estrus, n = 10). A tail-cuff system was used to measure blood pressure at 12 weeks of life. Parameters to evaluate renal function were taken into consideration. A significant increase in arterial pressure and a significant decrease in fractional sodium excretion were found in the androgenized animals compared to controls. There was no difference between the two groups with respect to glomerular filtration rate or in fractional potassium excretion. An increase in blood pressure and a reduction in fractional sodium excretion occur in female rats in persistent estrus. (AU)

• Processo FAPESP: 06/52431-1 - Nefrogenese em um modelo genetico de hipertensao arterial primaria: implicacoes no desenvolvimento hipertensivo de ratos espontaneamente hipertensos (shr).
• Beneficiário: Jose Antonio Rocha Gontijo
• Modalidade de apoio: Auxílio à Pesquisa - Regular