Circulating matrix metalloproteinase-8 (MMP-8) and MMP-9 are increased in chronic periodontal disease and decrease after non-surgical periodontal therapy

Autor(es)

Marcaccini, Andrea M. ^[1] ; Novaes, Jr., Arthur B. ^[1] ; Meschiari, Cesar A. ; Souza, Sergio L. ^[1] ; Palioto, Daniela B. ^[1] ; Sorgi, Carlos A. ^[2] ; Faccioli, Lucia H. ^[2] ; Tanus-Santos, Jose E. ^[3] ; Gerlach, Raquel F. ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Buccomaxillofacial Surg & Periodontol, BR-14040904 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Anal, BR-14040904 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pharmacol, BR-14040904 Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Fac Odontol Ribeirao Preto, Dept Morfol Estomatol & Fisiol, Sch Dent Ribeirao Preto, BR-14040904 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinica Chimica Acta; v. 409, n. 1-2, p. 117-122, NOV 3 2009.
• Citações Web of Science: 47

Resumo

Background: Periodontal disease shares risk factors with cardiovascular diseases and other systemic inflammatory diseases. The present study was designed to assess the circulating matrix metalloproteinases (MMPs) from chronic periodontal disease patients and, subsequently, after periodontal therapy. Methods: We compared the plasma concentrations of MMP-2. MMP-3, MMP-8, MMP-9, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2, and total gelatinolytic activity in patients with periodontal disease (n =28) with those of control subjects (n = 22) before and 3 months after non-surgical periodontal therapy. Results: Higher plasma MMP-3, MMP-8, and MMP-9 concentrations were found in periodontal disease patients compared with healthy controls (all P<0.05), whereas MMP-2, TIMP-1, and TIMP-2 levels were not different. Treatment decreased plasma MMP-8 and MMP-9 concentrations by 35% and 39%, respectively (both P<0.02), while no changes were found in controls. MMP-2, MMP-3, TIMP-1, and TIMP-2 remained unaltered in both groups. Plasma gelatinolytic activity was higher in periodontal disease patients compared with controls (P<0.001) and decreased after periodontal therapy (P<0.05). Conclusions: This study showed increased circulating MMP-8 and MMP-9 levels and proteolytic activity in periodontal disease patients that decrease after periodontal therapy. The effects of periodontal therapy suggest that it may attenuate inflammatory chronic diseases. (C) 2009 Published by Elsevier B.V. (AU)

• Processo FAPESP: 05/60527-6 - Perfil das metaloproteinases da matriz (MMPs) e inibidores teciduais das MMPs (TIMPs) no plasma, no fluído gengival e na saliva e sua correlação com marcadores plasmáticos de inflamação crônica em indivíduos com Doença Periodontal Crônica e indivíduos com saúde periodontal
• Beneficiário: Raquel Fernanda Gerlach
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/60526-0 - Correlação entre a metaloproteinase da matriz-9 (MMP-9) e marcadores inflamatórios plasmáticos em indivíduos com doença periodontal crônica antes e após o tratamento
• Beneficiário: Andréa Marcia Marcaccini
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado