The severity of epithelial dysplasia is associated with loss of maspin expression in actinic cheilitis

Autor(es)

Fontes, Alexandra ^[1] ; de Sousa, Suzana M. ^[1] ; dos Santos, Elisa ^[1] ; Martins, Marilia T. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Odontol, Disciplina Patol Bucal, BR-05508900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CUTANEOUS PATHOLOGY; v. 36, n. 11, p. 1151-1156, NOV 2009.
• Citações Web of Science: 5

Resumo

Background Prolonged exposure of the lip to sunlight may cause actinic cheilitis (AC) and squamous cell carcinoma (SCC). Maspin is a serpin with tumor suppressor functions. This work analyzed the presence and distribution of maspin in AC and lip SCC. Methods Sections from 36 cases diagnosed as AC (18 cases with mild epithelial dysplasia, 11 with moderate and 7 with severe), 18 cases diagnosed as lip SCC and 7 specimens containing normal lip vermillion epithelium were submitted for immunohistochemical analysis to detect maspin. Results All AC cases with mild and two cases with moderate dysplasia were scored 3. The remaining nine cases with moderate dysplasia were identified as score 2, whereas all cases with severe dysplasia were scored 1. Positive staining for maspin decreased from the basal layer to the surface. Among the 18 lip SCCs studied, 15 cases showed abundant staining for maspin. Epithelium adjacent to the SCCs also showed intense positive staining in all cells. Conclusions Our results suggest that the loss of maspin expression occurs from the basal layer to the surface. Lip SCCs related to solar radiation show an intense presence of maspin protein in almost all tumor cells as well as the neighboring epithelium. Fontes A, Sousa SM, Santos E, Martins MT. The severity of epithelial dysplasia is associated with loss of maspin expression in actinic cheilitis. (AU)

• Processo FAPESP: 04/07821-0 - Expressão da proteína maspin na Queilite Actínica
• Beneficiário: Alexandra Fontes da Costa
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 04/11922-7 - Expressao da proteina maspin na queilite actinica.
• Beneficiário: Marília Trierveiler Martins
• Modalidade de apoio: Auxílio à Pesquisa - Regular