The Elevated Interferon Gamma Production is an Important Immunological Marker in HAM/TSP Pathogenesis

Autor(es)

Montanheiro, P. A. ^[1] ; Penalva de Oliveira, A. C. ^[2] ; Smid, J. ^[2] ; Fukumori, L. M. I. ^[1] ; Olah, I. ^[1] ; Duarte, A. J. da S. ^[1] ; Casseb, J. ^{[2, 3, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Dept Dermatol, Lab Dermatol & Imunodedeficiencias, LIM 56, BR-05403000 Sao Paulo - Brazil

^[2] Inst Infectol Emilio Ribas, Sao Paulo - Brazil

^[3] Univ Sao Paulo, IMTSP, BR-05403000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Scandinavian Journal of Immunology; v. 70, n. 4, p. 403-407, OCT 2009.
• Citações Web of Science: 26

Resumo

Human T-lymphotropic virus type 1 (HTLV-1) is the agent of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), which may Occur in > 5% of patients during their lifetime. HTLV-1-infection causes disturbances in the immune system, and the viral load may also play an important role in the pathogenesis of HAM/TSP. Some cytokines are involved in the pathogenesis of this disorder. We have determined IL-2, IL-4, IL-10, IL-12 p70, IFN-gamma and TNF-alpha production among HTLV-1-infected subjects from our HTLV-out Clinic in Institute of Infectious `Emilio Ribas' in Sao Paulo city, Brazil. PBMC obtained from healthy controls (n = 32), asymptomatic HTLV-1 carriers (n = 68) and HAM/TSP patients (n = 44) were grown in the absence and in the presence of phytohaemagglutinin (PHA), and the supernatants' fluids were measured for cytokines production. IL-2 levels were increased in the a-symptomatic HTLV-1 carriers, and IFN-gamma was increased in both groups of patients (asymptomatic HTLV-1 carriers and more significantly among HAM/TSP patients). IL-4, IL-10, TNF-alpha and IL-12 p70 levels were not significantly increased on both groups of patients, as compared with controls. The major finding Of this Study is that IFN-gamma was an important cytokine for the HAM/TSP pathogenesis. Therefore, immune modulation of IFN-gamma may be critical to treat of HAM/TSP patients. (AU)

• Processo FAPESP: 04/00329-3 - Resposta linfoproliferativa nos diferentes estagios da infeccao pelo virus linfotropico de celulas t humanas do tipo 1 (htlv-i).
• Beneficiário: Ingrid Olah Do Nascimento
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 03/00841-3 - Quantificacao de carga proviral (dna e rna) de htlv-i por pcr em tempo real e comparacao do perfil de citocinas entre elisa e pcr em tempo real.
• Beneficiário: Patricia Aparecida Montanheiro
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 03/08901-5 - Quantificação de carga pró-viral de HTLV-I e perfil de citocinas entre ELISA e PCR em tempo real
• Beneficiário: Jorge Simao do Rosario Casseb
• Modalidade de apoio: Auxílio à Pesquisa - Regular