Determination of Analgesics (Dipyrone and Acetaminophen) in Pharmaceutical Preparations by Cyclic Voltammetry at a Copper(II) Hexacyanoferrate(III) Modified Carbon Paste Electrode

Autor(es)

Teixeira, Marcos F. S. ^[1] ; Marcolino-Junior, Luiz H. ^[2] ; Fatibello-Filho, Orlando ^[3] ; Moraes, Fernando C. ^[3] ; Nunes, Ronaldo S. ^[4]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Fac Ciencias & Tecnol, Dept Fis Quim & Biol, UNESP, BR-19060900 Presidente Prudente, SP - Brazil

^[2] Univ Fed Parana, Dept Quim, Curitiba, SP - Brazil

^[3] Univ Fed Sao Carlos, Dept Quim, BR-13560 Sao Carlos, SP - Brazil

^[4] USP, Dept Quim & Fis Mol, IQSC, Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CURRENT ANALYTICAL CHEMISTRY; v. 5, n. 4, p. 303-310, OCT 2009.
• Citações Web of Science: 17

Resumo

Copper(II) hexacyanoferrate(III) (CuHCF) modified carbon paste electrode was used for the electroanalytical determination of dipyrone and acetaminophen in pharmaceutical preparations by cyclic voltammetry. Several parameters were investigated for the optimization of the sensor such as composition of the electrode, electrolytic solution, effect of pH, scan rate of potential and interference. The best conditions were found for an electrode composition in mass of 20% CuHCF, 55% graphite and 25% mineral oil in acetate buffer containing 0.05 mol L(-1) of NaCl. The analytical curve was linear in the dipyrone and acetaminophen concentration ranged from 1.25 x 10(-5) mol L(-1) to 1.23 x 10(-3) and 2.84 x 10(-4) to 2.59 x 10(-3) mol L(-1) respectively, being successfully applied to the determination of dipyrone and acetaminophen in pharmaceutical preparations. The CuHCF modified carbon paste electrode presented comparable results to those obtained using iodimetry and ultraviolet spectrophotometry methods, respectively. (AU)

• Processo FAPESP: 06/07191-2 - Desenvolvimento de sensores eletroquímicos do tipo screen-printed para a determinação de espécies de interesse ambiental e farmacêutico
• Beneficiário: Luiz Humberto Marcolino Junior
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 05/01296-4 - Desenvolvimento de metodologia analítica empregando eletrodos modificados com oxo complexos polinucleares de rutênio encapsulado em zeolita
• Beneficiário: Marcos Fernando de Souza Teixeira
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores