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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Determination of Analgesics (Dipyrone and Acetaminophen) in Pharmaceutical Preparations by Cyclic Voltammetry at a Copper(II) Hexacyanoferrate(III) Modified Carbon Paste Electrode

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Author(s):
Teixeira, Marcos F. S. [1] ; Marcolino-Junior, Luiz H. [2] ; Fatibello-Filho, Orlando [3] ; Moraes, Fernando C. [3] ; Nunes, Ronaldo S. [4]
Total Authors: 5
Affiliation:
[1] Univ Estadual Paulista, Fac Ciencias & Tecnol, Dept Fis Quim & Biol, UNESP, BR-19060900 Presidente Prudente, SP - Brazil
[2] Univ Fed Parana, Dept Quim, Curitiba, SP - Brazil
[3] Univ Fed Sao Carlos, Dept Quim, BR-13560 Sao Carlos, SP - Brazil
[4] USP, Dept Quim & Fis Mol, IQSC, Sao Carlos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: CURRENT ANALYTICAL CHEMISTRY; v. 5, n. 4, p. 303-310, OCT 2009.
Web of Science Citations: 17
Abstract

Copper(II) hexacyanoferrate(III) (CuHCF) modified carbon paste electrode was used for the electroanalytical determination of dipyrone and acetaminophen in pharmaceutical preparations by cyclic voltammetry. Several parameters were investigated for the optimization of the sensor such as composition of the electrode, electrolytic solution, effect of pH, scan rate of potential and interference. The best conditions were found for an electrode composition in mass of 20% CuHCF, 55% graphite and 25% mineral oil in acetate buffer containing 0.05 mol L(-1) of NaCl. The analytical curve was linear in the dipyrone and acetaminophen concentration ranged from 1.25 x 10(-5) mol L(-1) to 1.23 x 10(-3) and 2.84 x 10(-4) to 2.59 x 10(-3) mol L(-1) respectively, being successfully applied to the determination of dipyrone and acetaminophen in pharmaceutical preparations. The CuHCF modified carbon paste electrode presented comparable results to those obtained using iodimetry and ultraviolet spectrophotometry methods, respectively. (AU)

FAPESP's process: 06/07191-2 - Screen-printed electrochemical sensors for determination of environmental and pharmaceutical species
Grantee:Luiz Humberto Marcolino Junior
Support Opportunities: Scholarships in Brazil - Post-Doctoral