Electrochemical studies and application of sensors based on graphene or 3-D reticuled glassy carbon modified with metal nanoparticles for determination of pharmaceuticals and environmental analytes.

• Grant number: 14/04284-6
• Support type: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): August 01, 2014
• Effective date (End): April 15, 2015
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal researcher: Orlando Fatibello Filho
• Grantee: Luiz Carlos Soares de Figueiredo Filho
• Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

In this postdoctoral project will be electrochemically studied, characterized and applied electrochemical electrodes based on graphene , tridimensional reticulated vitreous carbon (3D-RVC) or not modified with metal nanoparticles of gold and platinum.The nanoparticles will be previously synthesized (chemically) and surrounded by different protective molecules (surfactants, polyelectrolytes, and others) for their potential application as catalytic material at determination of organic species with pharmaceutical and environmental interest.After the proposed nanoparticle synthesis, it must be deposited in a film form and incorporated on a graphene or 3D-RVC substrate. The electrochemical characteristic of the sensors will be evaluated by electrochemical techniques, namely, cyclic voltammetry, cronoamperometry and electrochemical impedance spectroscopy. With such modifications, the objective is to improve significantly the detection properties of these electrochemical sensors, namely, diminishes of the overpontential work, increase of the current intensity (increase at the analytical signal), increase of sensitivity (increase of the slope of the analytical curve). Hereafter will be employed the use of electrochemical probe that presents a well known behave and extensively discussed at literature, like potassium hexacyaneferrate(III) or hexaammineruthenium(III) in such a way that the comparison/determination of the electroactive area, electronical transference constant and heterogeneous electronical transference constant can be made.For the results obtained by the analyses using graphene modified with metallic nanoparticles, comparisons with other types of carbonaceous electrodes will be made just like edge or basal plane pyrolytic graphite . After selection of the best experimental conditions the analytical parameters will be investigated, namely range of linear response, sensitivity, limits of detection, reproducibility and repeatability. Effects of potential interfering and study addition and recovery will also be evaluated.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VICENTINI, FERNANDO CAMPANHA; GARCIA, LIVIA L. C.; FIGUEIREDO-FILHO, LUIZ C. S.; JANEGITZ, BRUNO C.; FATIBELLO-FILHO, ORLANDO. A biosensor based on gold nanoparticles, dihexadecylphosphate, and tyrosinase for the determination of catechol in natural water. Enzyme and Microbial Technology, v. 84, p. 17-23, MAR 2016. Web of Science Citations: 45.

SANTOS, ANDERSON M.; VICENTINI, FERNANDO C.; FIGUEIREDO-FILHO, LUIZ C. S.; DEROCO, PATRICIA B.; FATIBELLO-FILHO, ORLANDO. Flow injection simultaneous determination of acetaminophen and tramadol in pharmaceutical and biological samples using multiple pulse amperometric detection with a boron-doped diamond electrode. DIAMOND AND RELATED MATERIALS, v. 60, p. 1-8, NOV 2015. Web of Science Citations: 18.

VICENTINI, FERNANDO CAMPANHA; RAVANINI, AMANDA E.; FIGUEIREDO-FILHO, LUIZ C. S.; INIESTA, JESUS; BANKS, CRAIG E.; FATIBELLO-FILHO, ORLANDO. Imparting improvements in electrochemical sensors: evaluation of different carbon blacks that give rise to significant improvement in the performance of electroanalytical sensing platforms. Electrochimica Acta, v. 157, p. 125-133, MAR 1 2015. Web of Science Citations: 53.

FIGUEIREDO-FILHO, LUIZ C. S.; SARTORI, ELEN R.; FATIBELLO-FILHO, O. Electroanalytical determination of the linuron herbicide using a cathodically pretreated boron-doped diamond electrode: comparison with a boron-doped diamond electrode modified with platinum nanoparticles. ANALYTICAL METHODS, v. 7, n. 2, p. 643-649, 2015. Web of Science Citations: 16.