| Texto completo | |
| Autor(es): |
Yai, Lucia E. O.
[1]
;
Ragozo, Alessandra M. A.
[2]
;
Soares, Rodrigo M.
[2]
;
Pena, Hilda F. J.
[2]
;
Su, C.
[3]
;
Gennari, Solange M.
[2]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Ctr Controle Zoonoses, BR-02039020 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Med Vet Prevent & Saude Anim, Fac Med Vet & Zootecnia, BR-05508270 Sao Paulo - Brazil
[3] Univ Tennessee, Dept Microbiol, Knoxville, TN 37996 - USA
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Veterinary Parasitology; v. 162, n. 3-4, p. 332-337, JUN 10 2009. |
| Citações Web of Science: | 34 |
| Resumo | |
Recent studies indicate that Toxoplasma gondii isolates of many domestic hosts from Brazil are genetically and biologically different from T. gondii isolates from USA and Europe. However, little is known about genetics of T. gondii isolates from wild mammals in Brazil. In this study, genotypes of 36 T gondii isolates from capybaras (Hydrochaeris hydrochaeris) from six counties in Sao Paulo state, Brazil, were determined. Sixteen genotypes were identified using 11 genetic markers including SAG1, SAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1, Apico and CS3. No classical clonal Type I and Type 11 isolates were found, confirming other findings that these lineages are rare in Brazil. Eight of these 36 isolates were grouped into the common clonal lineages in Brazil, previously designed as Types BrI, BrII and BrIII. Seven of the 16 genotypes were reported for the first time in this study. Three of the 36 isolates showed mixed infections. Analysis of mortality rates in infected mice indicated that Type BrI is highly virulent, Type BrII is intermediately virulent and Type BrIII is non-virulent, which is in agreement with previous report. The allele types at the CS3 locus are strongly linked to mouse-virulence of the parasite. These genotyping results support previous findings that the T. gondii population is highly diverse in Brazil. (C) 2009 Elsevier B.V. All rights reserved. (AU) | |
| Processo FAPESP: | 06/53745-0 - Caracterizacao genotipica de isolados brasileiros de toxoplasma gondii provenientes de gatos, ovinos, caprinos suinos e capivaras atraves de pcr-rflp multilocus. |
| Beneficiário: | Hilda Fátima de Jesus Pena |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |